Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion

Kirchhoff, Philipp; Socrates, Thenral; Sidani, Shafik; Duffy, Andrew; Breidthardt, Tobias; Grob, Christian; Viehl, Carsten T.; Beglinger, Christoph; Oertli, Daniel; Geibel, John P.
January 2011
American Journal of Gastroenterology;Jan2011, Vol. 106 Issue 1, p62
Academic Journal
OBJECTIVES:The overproduction of acid and the associated illnesses linked to hypersecretion have a lifetime prevalence of 25-35% in the United States. Although a variety of pharmaceutical agents have been used to reduce the production of acid, alarming new evidence questions the long-term efficacy and safety of the agents. These issues coupled with the delayed onset of action and the return of symptoms in over 60% of the patients is less than satisfactory. The purpose of this study was to determine whether administration of a zinc salt could lead to a rapid and sustained increase in gastric pH in both animals and in humans and provide a new rapid acid suppression therapy.METHODS:Intracellular pH was measured with 2′,7′-bis-(2-carboxyethyl)-5-and-6-carboxy-fluorescin in both human and rat gastric glands following an acid load±a secretagogue. In a separate series of studies, whole stomach acid secretion was monitored in rats. A final study used healthy human volunteers while monitoring with a gastric pH measurement received placebo, zinc salt, or a zinc salt and proton pump inhibitor (PPI).RESULTS:We demonstrate that exposure to ZnCl2 immediately abolished secretagogue-induced acid secretion in isolated human and rat gastric glands, and in intact rat stomachs. Chronic low-dose zinc exposure effectively inhibited acid secretion in whole stomachs and isolated glands. In a randomized cross-over study in 12 volunteers, exposure to a single dose of ZnCl2 raised intragastric pH for over 3 h, including a fast onset of effect.CONCLUSIONS:Our findings demonstrate that zinc offers a novel rapid and prolonged therapy to inhibit gastric acid secretion in human and rat models.


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