TITLE

Glucocorticoid receptor expression and glucocorticoid therapeutic effect in nasal polyps

AUTHOR(S)
Peng Li; Yuan Li; Yong-Qi Li; Qin-Tai Yang; Ge-Hua Zhang
PUB. DATE
June 2010
SOURCE
Clinical & Investigative Medicine;Jun2010, Vol. 33 Issue 3, pE181
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To investigate the expression and quantity of glucocorticoid receptor-α and -β in polyp tissues taken from the patients treated were subsequently treated with topical glucocorticoid (GC). Methods: Eighty patients with nasal polyps were initially enrolled in the study. All polyp specimens were obtained prior to treatment. Patients then received daily topical GC spray treatment for one month. Polyp specimens were tested for glucocorticoid receptor (GR) GR-α and GR-β mRNA expression using fluorescent quantitative-reverse transcription-polymerase chain reaction (FQ-RT-PCR). Thirty healthy nasal mucosa tissue samples were tested at the same time. Results: Forty patients finished the study and were divided into two groups: GC-sensitive (n=26) and GC-insensitive (n=14), according to treatment results. GR-β mRNA expression in the nasal polyp tissues of the GC-insensitive group (5.72±0.58×10² copies/μg) was higher than that in the GC-sensitive group (4.82±0.28×10² copies/μg, P<0.05) and in the normal nasal mucosa group (4.44±0.35×10² copies/μg, P<0.01). There was also a difference in the relative expression of GR-α and GR-β between the GC-sensitive group (GR-α/GR-β= 829.42±67.36) and the GC-insensitive group (535.7±89) (P<0.01). Conclusion: GR-β mRNA was highly expressed in patients with nasal polyps. Down-regulation of GR-α mRNA suggests the existence of glucocorticoid insensitivity. Expression of GR-β may plays an important role in the evaluation of the glucocorticoid therapeutic effect in patients with nasal polyps.
ACCESSION #
57154038

 

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