TITLE

Bases clínicas y genéticas de la nefroesclerosis hipertensiva. Estudio NEFROSEN

AUTHOR(S)
Ojea, B. Diez; Marín, R.; Coto, E.; Vega, F. Fernández; Navascués, R. Álvarez; Fresnedo, G. Fernández; de Salinas, A. Pobes Martínez; Laurés, A. Suárez; Monteavaro, C. García; Gorostidi, M.; Sánchez, E.; Arias, M.; Ortega, F.
PUB. DATE
December 2010
SOURCE
Nefrologia;2010, Vol. 30 Issue 6, p687
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Hypertensive nephrosclerosis is a chronic kidney disease (CKD) associated withto essential hypertension. The lack of correlation between hypertension control and progression to end-stageof CKD suggests an intrinsic and primitive disease. New evidence suggests that MYH9 gene alterations are associated with polymorphisms in African Americans. The aim of this study is to investigate whether a polymorphism of MYH9 in Caucasians is linked to essential hypertension and nephrosclerosis. The secondary objective is to identify the clinical risk factors of progression to end-stage renal disease (ESRD)end-stage CKD. This is a retrospective study that will compare patients with nephrosclerosis versus and essential hypertensives without renal disease, and also patients with nephrosclerosis and impaired renal function versus with those that are stable. Method: Between October 2009 and October 2010, 500 patients with stages 3-5 CKD attributed to nephrosclerosis according to usual clinical criteria, and 300 essential hypertensives (eGFR>60mL/min/1.73m2; microalbuminuria <300mg/g) are to be recruited. A total of 200 healthy controls from the general population are also to be included for the genetic study. There are two study sections, being the first and final visits to the clinic (for stage 5 cases, the start of replacement therapy will be the end of follow-up). Clinical and laboratory data will be recorded, and blood samples will be collected. Discussion:n Our study will aim to determine if there exists is a relationship between the diagnosis of nephrosclerosis and the MYH9 gene in Caucasiansthe Caucasia race, and to study possible risk factors for progression to ESRDend-stage CKD, on both clinical and genetic baseis.
ACCESSION #
56947153

 

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