Combination photodynamic therapy and bevacizumab for choroidal neovascularization associated with toxoplasmosis

Rishi, Pukhraj; Venkataraman, Anusha; Rishi, Ekta
January 2011
Indian Journal of Ophthalmology;Jan2011, Vol. 59 Issue 1, p62
Academic Journal
A 14-year-old girl presenting with visual loss in both eyes was diagnosed to have healed toxoplasma retinochoroiditis in the right eye with active choroidal neovascularization (CNV) secondary to toxoplasmosis in the left. She underwent combination photodynamic therapy (PDT) and intravitreal bevacizumab as primary treatment. PDT was performed as per the 'Treatment of Age-related Macular Degeneration by Photodynamic therapy' study protocol and was followed by intravitreal bevacizumab after 2 days. CNV regressed at 8 weeks of follow-up and remained stable at 8 months of follow-up. The initial visual acuity improved from 20/120 to 20/30. Combination therapy with PDT and intravitreal bevacizumab appears to be effective in the treatment of CNV secondary to toxoplasma retinochoroiditis.


Related Articles

  • Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration. Markus Ladewig; Stefanie Karl; Victoria Hamelmann; Hans-Martin Helb; Hendrik Scholl; Frank Holz; Nicole Eter // Graefe's Archive of Clinical & Experimental Ophthalmology;Jan2008, Vol. 246 Issue 1, p17 

    Abstract Background  Our aim was to evaluate the short-term safety and efficacy of combined photodynamic therapy (PDT) with verteporfin and intravitreal bevacizumab in neovascular age-related macular degeneration (AMD). Methods  A prospective non-randomized...

  • One-year results of bevacizumab intravitreal and posterior sub-Tenon injection of triamcinolone acetonide with reduced laser fluence photodynamic therapy for retinal angiomatous proliferation. Shirakata, Yukari; Shiragami, Chieko; Yamashita, Ayana; Nitta, Eri; Fujiwara, Atsushi; Shiraga, Fumio // Japanese Journal of Ophthalmology;Nov2012, Vol. 56 Issue 6, p599 

    Purpose: Our aim was to study the efficacy of combined triple therapy with intravitreal bevacizumab injections (IVB), posterior sub-Tenon injection of triamcinolone acetonide (STTA), and reduced laser fluence photodynamic therapy (RFPDT) in Japanese patients with retinal angiomatous...

  • Low fluence rate photodynamic therapy combined with intravitreal bevacizumab for neovascular age-related macular degeneration. Costagliola, Ciro; Romano, Mario R.; Rinaldi, Michele; dell'Omo, Roberto; Chiosi, Flavia; Menzione, Massimo; Semeraro, Francesco // British Journal of Ophthalmology;Feb2010, Vol. 94 Issue 2, p180 

    Aims To report the efficacy and safety of intravitreal bevacizumab (IVB) alone versus IVB plus low-fluence photodynamic therapy (PDT) in age-related macular degeneration (AMD) patients and to verify the occurrence of a synergistic effect of the combined approach on visual acuity, size and...

  • Photodynamic Therapy with Verteporfin for Corneal Neovascularization. Al-Torbak, Abdullah A. // Middle East African Journal of Ophthalmology;Apr-Jun2012, Vol. 19 Issue 2, p185 

    Purpose: To investigate the efficacy of photodynamic therapy (PDT) with verteporfin for the treatment of patients with corneal neovascularization. Materials and Methods: Retrospective interventional case series of 33 eyes of 32 patients with stable corneal neovascularization who were refractory...

  • Intravitreal bevacizumab versus photodynamic therapy for myopic choroidal neovascularization in a North-African population. El Matri, Leila; Kort, Fedra; Chebil, Ahmed; Bouraoui, Rim; Merdassi, Ahlem; Bouladi, Mejda // Graefe's Archive of Clinical & Experimental Ophthalmology;Sep2011, Vol. 249 Issue 9, p1287 

    Purpose: To compare the 1-year functional and anatomical outcomes of intravitreal bevacizumab (IVB) and photodynamic therapy (PDT) in patients with myopic choroidal neovascularization (CNV). Methods: Review of retrospectively collected data of 80 eyes in 80 patients with myopic CNV treated with...

  • Intravitreous bevacizumab to treat subfoveal choroidal neovascularization in highly myopic eyes: short-term results. Ruiz-Moreno, J. M.; Gomez-Ulla, F.; Montero, J. A.; Ares, S.; Lopez-Lopez, F.; Rodriguez, M.; Fernandez, M. // Eye;Feb2009, Vol. 23 Issue 2, p334 

    AimTo describe the anatomical and visual outcome of subfoveal and juxtafoveal choroidal neovascularization (CNV) in highly myopic eyes treated by intravitreal bevacizumab.MethodsProspective, nonrandomized, multicentric, interventional pilot study. Twenty-six highly myopic eyes from 25 patients...

  • Treatment of Choroidal Neovascularization in High Myopia. Montero, Javier A.; Ruiz-Moreno, Jose M. // Current Drug Targets;May2010, Vol. 11 Issue 5, p630 

    High myopia affects approximately 2% of general population, and is a major cause of legal blindness in many developed countries. Choroidal neovascularization (CNV) is the most common vision-threatening complication of high myopia. Different therapeutic approaches have been attempted such as...

  • Choroidal neovascularization associated with coloboma of the choroid: A series of three cases. Bhende, Muna; Suganeswari, G.; Gopal, Lingam; Bhende, Pramod S.; Gopal, Lekha; Rao, Chetan // Indian Journal of Ophthalmology;Mar2011, Vol. 59 Issue 2, p148 

    Choroidal neovascularization (CNV) is a rare complication associated with coloboma of the choroid. We describe three cases of coloboma choroid where there was loss of vision due to CNV development at the edge of the coloboma. One was managed by photodynamic therapy alone and two were managed by...

  • Effects of photodynamic therapy on the choriocapillaris and retinal pigment epithelium in the irradiated area. Nadia Dewi; Mitsuko Yuzawa; Kasumi Tochigi; Akiyuki Kawamura; Ryusaburo Mori // Japanese Journal of Ophthalmology;Jul2008, Vol. 52 Issue 4, p277 

    Abstract Purpose  To evaluate the effect of photodynamic therapy (PDT) on the choriocapillaris and retinal pigment epithelium (RPE) in the irradiated area surrounding choroidal neovascularization (CNV) during 12 months of follow-up. Methods  We reviewed the medical records, and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics