TITLE

X-ray spectromicroscopy studies of protein-polymer Interactions

AUTHOR(S)
Hitchcock, A. P.; Tyliszczak, T.; Heng, Y. M.; Cornelius, R.; Brash, J. L.; Ade, H.; Anders, S.; Scholl, A.; Nolting, F.
PUB. DATE
May 2000
SOURCE
AIP Conference Proceedings;2000, Vol. 507 Issue 1, p235
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Identification of the sites of protein binding on laterally heterogeneous polymer surfaces can help understand mechanisms of bio-passivation, which in turn has practical impact on developing improved polymers for medical uses, such as blood contact applications. We have used scanning X-ray transmission microscopy and photoelectron emission microscopy to explore the sensitivity of these X-ray microscopies to detection of human serum albumin adsorbed onto the surface of two different polyurethane polymers. Both techniques appear capable of the requisite monolayer sensitivity.
ACCESSION #
5664428

 

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