A Role for Receptor-Operated Ca2+ Entry in Human Pulmonary Artery Smooth Muscle Cells in Response to Hypoxia

December 2010
Physiological Research;2010, Vol. 59 Issue 6, p909
Academic Journal
No abstract available.


Related Articles

  • Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells. Parpaite, Thibaud; Cardouat, Guillaume; Mauroux, Marthe; Gillibert-Duplantier, Jennifer; Robillard, Paul; Quignard, Jean-François; Marthan, Roger; Savineau, Jean-Pierre; Ducret, Thomas // Pflugers Archiv European Journal of Physiology;Jan2016, Vol. 468 Issue 1, p111 

    Transient receptor potential (TRP) channels of the vanilloid subfamily, mainly TRPV1 and TRPV4, are expressed in pulmonary artery smooth muscle cells (PASMC) and implicated in the remodeling of pulmonary artery, a landmark of pulmonary hypertension (PH). Among a variety of PH subtypes, PH of...

  • Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. Martín-Aragón Baudel, Miguel A. S.; Shi, Jian; Large, William A.; Albert, Anthony P. // Cells (2073-4409);Jan2020, Vol. 9 Issue 1, p1 

    In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the development of vascular diseases. It is...

  • Hypoxia Modulates Cyclic AMP Activation of BKCa Channels in Rat Pulmonary Arterial Smooth Muscle. Barman, Scott A.; Shu Zhu; White, Richard E. // Lung;2005, Vol. 183 Issue 5, p353 

    The signal transduction mechanisms defining the role of eye he nucleotides in the regulation of potassium channel activity in pulmonary vascular smooth muscle are currently an area of great interest. Normally, signaling mechanisms that elevate cyclic AMP (cAMP) open potassium channels....

  • High expression of calcium channel subtypes in uterine fibroid of patients. Xiaoping Ke; Zhongping Cheng; Xiaoyan Qu; Hong Dai; Wenchao Zhang; Zi-Jiang Chen // International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 5, p1324 

    Aim: To investigate the expression of calcium channel protein in uterine fibroids, and to explore the relationship between calcium signaling pathway and the pathogenesis of uterine fibroids. Methods: Uterine fibroid tissues (UFC) and adjacent healthy uterine smooth muscle tissues (SMC) were...

  • Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A. Thorin-Trescases, Nathalie; Orlov, Sergei N; Taurin, Sébastien; Dulin, Nickolai O; Allen, Bruce G; deBlois, Denis; Tremblay, Johanne; Pshezhetsky, Alexei V; Hamet, Pavel // Canadian Journal of Physiology & Pharmacology;Jun2001, Vol. 79 Issue 6, p471 

    The effect of cholera toxin (CTX), an activator of the adenylate cyclase-coupled G protein α[sub S] subunit, was studied on cultured vascular smooth muscle cell (VSMC) proliferation. Continuous exposure (48 h) to CTX as well as 2-min pretreatment of VSMC with CTX led to the same level of cAMP...

  • cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum. Lusche, Daniel F.; Bezares-Roder, Karen; Happle, Kathrin; Schlatterer, Christina // BMC Cell Biology;2005, Vol. 6, p1 

    Background: Differentiating Dictyostelium discoideum amoebae respond upon cAMP-stimulation with an increase in the cytosolic free Ca2+ concentration ([Ca2+]i) that is composed of liberation of stored Ca2+ and extracellular Ca2+-influx. In this study we investigated whether intracellular cAMP is...

  • NOX4 Mediates BMP4-Induced Upregulation of TRPC1 and 6 Protein Expressions in Distal Pulmonary Arterial Smooth Muscle Cells. Jiang, Qian; Fu, Xin; Tian, Lichun; Chen, Yuqin; Yang, Kai; Chen, Xiuqing; Zhang, Jie; Lu, Wenju; Wang, Jian // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Rationale: Our previous studies demonstrated that bone morphogenetic protein 4 (BMP4) mediated, elevated expression of canonical transient receptor potential (TRPC) largely accounts for the enhanced proliferation in pulmonary arterial smooth muscle cells (PASMCs). In the present study, we...

  • The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Zhao, Lan; Oliver, Eduardo; Maratou, Klio; Atanur, Santosh S.; Dubois, Olivier D.; Cotroneo, Emanuele; Chen, Chien-Nien; Wang, Lei; Arce, Cristina; Chabosseau, Pauline L.; Ponsa-Cobas, Joan; Frid, Maria G.; Moyon, Benjamin; Webster, Zoe; Aldashev, Almaz; Ferrer, Jorge; Rutter, Guy A.; Stenmark, Kurt R.; Aitman, Timothy J.; Wilkins, Martin R. // Nature;8/20/2015, Vol. 524 Issue 7565, p356 

    The typical response of the adult mammalian pulmonary circulation to a low oxygen environment is vasoconstriction and structural remodelling of pulmonary arterioles, leading to chronic elevation of pulmonary artery pressure (pulmonary hypertension) and right ventricular hypertrophy. Some...

  • Serine 68 Phospholemman Phosphorylation during Forskolin-Induced Swine Carotid Artery Relaxation. Rembold, Christopher M.; Ripley, Marcia L.; Meeks, Melissa K.; Geddis, Lisa M.; Kutchai, Howard C.; Marassi, Francesca M.; Cheung, Joseph Y.; Moorman, J. Randall // Journal of Vascular Research;2005, Vol. 42 Issue 6, p483 

    Background: Phospholemman (PLM) is an abundant phosphoprotein in the plasma membrane of cardiac, skeletal and smooth muscle. It is a member of the FXYD family of proteins that bind to and regulate the Na,K-ATPase. Protein kinase A (PKA) is known to phosphorylate PLM on serine 68 (S68), although...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics