TITLE

Primary Signet Ring Cell Carcinoma of the Prostate

AUTHOR(S)
Warner, Jonathan N.; Nakamura, Leah Y.; Pacelli, Anna; Humphreys, Mitchell R.; Castle, Erik P.
PUB. DATE
December 2010
SOURCE
Mayo Clinic Proceedings;Dec2010, Vol. 85 Issue 12, p1130
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nine patients treated with primary signet ring cell carcinoma of the prostate were identified among 29,783 cases of prostate cancer evaluated at Mayo Clinic from January 15, 1970, until January 2, 2009. A PubMed search of the English-language literature published from January 1, 1980, to January 1, 2010, was then performed using the key words signet ring cell and prostate, identifying 42 cases. This study reviews those cases, along with the additional 9 reported herein, and evaluates clinical characteristics, histologic diagnoses, treatment modalities, and outcomes. Mean age at diagnosis was 68 years (range, 50-85 years), and mean prostate-specific antigen level was 95.3 ng/mL (range, 1.9- 536.0 ng/mL; to convert to μg/L, multiply by 1). Most patients (66%) had non-stage IV carcinoma, the most common Gleason sum was 8 (33%), and mean survival was 29 months. The presence of a primary signet ring cell carcinoma of the prostate was best confirmed by negative findings on gastrointestinal work-up, a positive stain for prostate-specific acid phosphatase, and negative carcinoembryonic antigen test results.
ACCESSION #
56570980

 

Related Articles

  • Frequency of Positive Surgical Margin at Prostatectomy and Its Effect on Patient Outcome. Iczkowski, Kenneth A.; Lucia, M. Scott // Prostate Cancer (20903111);2011, p1 

    A positive surgical margin at prostatectomy is defined as tumor cells touching the inked edge of the specimen. This finding is reported in 8.8% to 42% of cases (median about 20%) in various studies. It is one of the main determinants of eventual biochemical (PSA) failure, generally associated...

  • Leonhard Euler. Aliprandini, Michael // Leonhard Euler;8/1/2017, p1 

    Background information on eighteenth-century mathematician Leonhard Euler is presented. The author reviews how Euler revolutionized the field of mathematics, contributing to differential calculus, algebra, geometry, trigonometry, topology, and number theory. A prolific writer, he left hundreds...

  • Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. Lin, H-M; Castillo, L; Mahon, K L; Chiam, K; Lee, B Y; Nguyen, Q; Boyer, M J; Stockler, M R; Pavlakis, N; Marx, G; Mallesara, G; Gurney, H; Clark, S J; Swarbrick, A; Daly, R J; Horvath, L G // British Journal of Cancer;5/13/2014, Vol. 110 Issue 10, p2462 

    Background:Docetaxel is the first-line chemotherapy for castration-resistant prostate cancer (CRPC). However, response rates are ∼50% and determined quite late in the treatment schedule, thus non-responders are subjected to unnecessary toxicity. The potential of circulating microRNAs as...

  • The origin of prostate metastases: emerging insights. Santoni, Matteo; Piva, Francesco; Scarpelli, Marina; Cheng, Liang; Lopez-Beltran, Antonio; Massari, Francesco; Iacovelli, Roberto; Berardi, Rossana; Santini, Daniele; Montironi, Rodolfo // Cancer & Metastasis Reviews;Dec2015, Vol. 34 Issue 4, p765 

    The outcome of patients with prostate cancer (PCa) is mainly dependent on the presence or absence of distant metastases. Although several advances have been made in understanding the biological basis of this tumor, the mechanisms underlying PCa metastatic spread are not fully clear. The lack of...

  • Interaction between c-jun and Androgen Receptor Determines the Outcome of Taxane Therapy in Castration Resistant Prostate Cancer. Tinzl, Martina; Chen, Binshen; Chen, Shao-Yong; Semenas, Julius; Abrahamsson, Per-Anders; Dizeyi, Nishtman // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Taxane based chemotherapy is the standard of care treatment in castration resistant prostate cancer (CRPC). There is convincing evidence that taxane therapy affects androgen receptor (AR) but the exact mechanisms have to be further elucidated. Our studies identified c-jun as a crucial key player...

  • CEA.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p394 

    An encyclopedia entry for "CEA," which refers to carcinoembryonic antigen, is presented.

  • Arguments against investing widely in robotic prostatectomy in Canada: a wrong focus on tool box rather than surgical expertise. Fradet, Yves // Canadian Urological Association Journal;Dec2009, Vol. 3 Issue 6, p486 

    The article presents arguments on the robotic-assisted minimally invasive radical prostatectomy (MIRP) in Canada. It explains the reason of the robotic MIRP's adoption in the U.S., which is the tool's ability to help the achievement of excellent results in prostate cancer removal by surgeon...

  • Safety of Vitamins and Minerals: Controversies and Perspective. Soni, Madhu G.; Thurmond, T. Scott; Miller, Edgar R.; Spriggs, Tracey; Bendich, Adrianne; Omaye, Stanley T. // Toxicological Sciences;Dec2010, Vol. 118 Issue 2, p348 

    Available information suggests that currently over 47% of males and 59% of females use dietary supplements for health benefits, and the number of users is rapidly increasing. However, numerous studies published over more than a decade have linked some supplements (including vitamins E, C, D, A,...

  • Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. D. Olmos; H.-T. Arkenau; J. E. Ang; I. Ledaki; G. Attard; C. P. Carden; A. H. M. Reid; R. AHern; P. C. Fong; N. B. Oomen; R. Molife; D. Dearnaley; C. Parker; L. W. M. M. Terstappen; J. S. de Bono // Annals of Oncology;Jan2009, Vol. 20 Issue 1, p27 

    Background: The purpose of this study was to evaluate the association of circulating tumour cell (CTC) counts, before and after commencing treatment, with overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Experimental design: A 7.5 ml of blood was collected...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics