TITLE

Tetralogy of Fallot Repair in Patients 40 Years or Older

AUTHOR(S)
Jost, Christine H. Attenhofer; Connolly, Heidi M.; Burkhart, Harold M.; Scott, Christopher G.; Dearani, Joseph A.; Carroll, Aisling J.; Tajik, A. Jamil
PUB. DATE
December 2010
SOURCE
Mayo Clinic Proceedings;Dec2010, Vol. 85 Issue 12, p1090
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To report the outcomes of patients with tetralogy of Faliot (TOF) undergoing surgical repair at age 40 years or older. PATIENTS AND METHODS: We reviewed records of patients (age, ≥40 years) who underwent TOF repair from January 1, 1970, through December 31, 2007. Symptoms, palliative procedures, surgical reports, and long-term outcomes were analyzed. RESULTS: Fifty-two patients (30 men [58%]) had surgery at a mean ± SD age of 50±8 years; 27 (52%) had prior palliative surgery at a mean ± SD age of 17±11 years. Procedures for TOF repair included pulmonary valve replacement (n=10), transannular patch (n=10), and native pulmonary valve preservation (n=32). The 30-day mortality rate was 6% (stroke, n=2; ventricular fibrillation, n=1). A mean ± SD follow-up of 14.9±9.3 years was feasible in 48 of 49 survivors; improvement in functional class was observed in 42 patients. Reoperation was performed In 7 patients (4 for pulmonary regurgitation). Twenty-nine patients died (mean ± SD age, 65±12 years); causes of death were cardiac (n=7), noncardiac (n=4), and unknown (n=18). Mean ± SD age at death was younger in patients with previous palliation (59±11 years vs 70±12 years; P=.03). The 10-year survival rate was lower than expected compared with an age- and sex-matched population (73% vs 91%; P<.001). CONCLUSION: Complete repair of TOF In patients 40 years or older is feasible but carries Increased operative risk. Surgical survivors have Improvement In functional class; however, survival remains lower than expected. Reduced survival and need for reoperation emphasize the importance of pulmonary valve replacement at the time of initial repair and long-term follow-up.
ACCESSION #
56570975

 

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