Statin Therapy and Decreased Incidence of Positive Candida Cultures Among Patients With Type 2 Diabetes Mellitus Undergoing Gastrointestinal Surgery

Spanakis, Elias K.; Kourkoumpetis, Themistoklis K.; Livanis, Grigorios; Peleg, Anton Y.; Mylonakis, Eleftherios
December 2010
Mayo Clinic Proceedings;Dec2010, Vol. 85 Issue 12, p1073
Academic Journal
OBJECTIVE: To assess whether statin therapy decreases the Incidence of cultures positive for Candida species among high-risk hospitalized patients with type 2 diabetes mellitus (DM). PATIENTS AND METHODS: We performed a retrospective cohort study analyzing the records of all patients with type 2 DM who we!e admitted to Massachusetts General Hospital for lower gastrointestinal tract surgery between January 1, 2001, and May 1, 2008. We defined statin exposure as the filling of at least 1 prescription of statins during the 6 months before hospitalization or during the current hospital stay. The primary outcome was a culture positive for Candida species during hospitalization. Clinical Information on a wide range of covarlates was collected. Logistic regression analysis was used to adjust for possible confounders. RESULTS: Of the 1019 patients who were eligible for the study, 493 (48%) were receiving statins. A total of 139 patients (14%) had at least 1 culture positive for Candida species during hospitalization. An adjusted multivarlate model based on a backward stepwise elimination procedure showed that statin therapy significantly decreased the incidence of cultures positive for Candida species (odds ratio, 0.60; 95% confidence Interval [CI],; P=.03) with a statistically significant prolonged time to event compared with no statin therapy (adjusted hazard ratio, 0.62; 95% CI, 0.440.88; P=.01). The benefit of statins was more prominent in patients with type 2 DM who had greater comorbidities (Charison Comorbidity index ≥2) (adjusted odds ratio, 0.47; 95% CI, 0.27-0.79; P=.01). CONCLUSION: Among patients with type 2 DM who underwent gastrointestinal surgery, use of statins correlated with a decreased incidence of cultures positive for Candida species.


Related Articles

  • Statins and Diabetes: The Plot Thickens. Gastaldi, Giacomo; Philippe, Jacques // JGIM: Journal of General Internal Medicine;Nov2015, Vol. 30 Issue 11, p1572 

    The article looks into the association between the use of statin therapy and the development of type 2 diabetes. The results of several studies, including a retrospective cohort study by researcher I. Mansi and colleagues, which examined such association are discussed. The author suggests that...

  • Statin benefits outweigh risk of developing diabetes.  // Pulse;2/24/2010, Vol. 70 Issue 6, p11 

    The article explores the benefits of statins that outweigh the risk of developing type 2 diabetes.

  • 398 Effect of statins on the course of CHF in patients with type 2 diabetes mellitus.  // European Journal of Heart Failure. Supplements;Jun2005, Vol. 4 Issue 1, p88 

    An abstract of the article "Effect of Statins on the Course of CHF in Patients With Type 2 Diabetes Mellitus," by G. Arutyunov and A. Beituganov is presented.

  • Clinical briefs.  // New Zealand Doctor;3/10/2010, p24 

    This section offers clinical news briefs including the role of statins in raising the relative risk of developing type 2 diabetes by nine percent, the risk posed by paroxetine to women taking tamoxifen for breast cancer, and the role of aspirin in helping women with breast cancer survive.

  • Experts debate statin acceleration of type 2 diabetes development.  // Endocrine Today;Mar2014, Vol. 12 Issue 3, p20 

    The article presents a discussion among medical experts on the issue of statin therapy and acceleration of type 2 diabetes.

  • Role of Simvastatin as an Immunomodulator in Type 2 Diabetes. Petrou, Michelle; Gregoriades, Marialena; Vassiliou, Vassilios // Diabetes Care;Aug2004, Vol. 27 Issue 8, p2093 

    Presents a letter to the editor about the role of simvastatin as an immunomodulator in patients with type 2 diabetes.

  • Statins delay initiation of insulin in type 2 diabetes.  // Geriatrics;Aug2002, Vol. 57 Issue 8, p35 

    Suggests that use of statins may delay the initiation of insulin therapy in patients with type 2 diabetes, according to a study presented at the annual meeting of the American Diabetes Association in June 2002 in San Francisco, California. Mechanism of action; Methodology; Interpretation of...

  • Atorvastatin.  // Reactions Weekly;7/9/2011, Issue 1359, p10 

    The article describes three cases of patients with a history of type 2 diabetes mellitus (DM) and dyslipidaemia who developed rhabdomyolysis while receiving treatment with atorvastatin.

  • Statins linked to increased risk for type 2 diabetes.  // Canadian Nursing Home;Jun/Jul2015, Vol. 26 Issue 2, p9 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics