TITLE

Statin Therapy and Decreased Incidence of Positive Candida Cultures Among Patients With Type 2 Diabetes Mellitus Undergoing Gastrointestinal Surgery

AUTHOR(S)
Spanakis, Elias K.; Kourkoumpetis, Themistoklis K.; Livanis, Grigorios; Peleg, Anton Y.; Mylonakis, Eleftherios
PUB. DATE
December 2010
SOURCE
Mayo Clinic Proceedings;Dec2010, Vol. 85 Issue 12, p1073
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To assess whether statin therapy decreases the Incidence of cultures positive for Candida species among high-risk hospitalized patients with type 2 diabetes mellitus (DM). PATIENTS AND METHODS: We performed a retrospective cohort study analyzing the records of all patients with type 2 DM who we!e admitted to Massachusetts General Hospital for lower gastrointestinal tract surgery between January 1, 2001, and May 1, 2008. We defined statin exposure as the filling of at least 1 prescription of statins during the 6 months before hospitalization or during the current hospital stay. The primary outcome was a culture positive for Candida species during hospitalization. Clinical Information on a wide range of covarlates was collected. Logistic regression analysis was used to adjust for possible confounders. RESULTS: Of the 1019 patients who were eligible for the study, 493 (48%) were receiving statins. A total of 139 patients (14%) had at least 1 culture positive for Candida species during hospitalization. An adjusted multivarlate model based on a backward stepwise elimination procedure showed that statin therapy significantly decreased the incidence of cultures positive for Candida species (odds ratio, 0.60; 95% confidence Interval [CI], 0.38.0.96; P=.03) with a statistically significant prolonged time to event compared with no statin therapy (adjusted hazard ratio, 0.62; 95% CI, 0.440.88; P=.01). The benefit of statins was more prominent in patients with type 2 DM who had greater comorbidities (Charison Comorbidity index ≥2) (adjusted odds ratio, 0.47; 95% CI, 0.27-0.79; P=.01). CONCLUSION: Among patients with type 2 DM who underwent gastrointestinal surgery, use of statins correlated with a decreased incidence of cultures positive for Candida species.
ACCESSION #
56570973

 

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