Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency

November 2009
PLoS ONE;2009, Vol. 4 Issue 11, p1
Academic Journal
The article focuses on a study on knock-out mice to examine the in vivo effect of estrogen-receptor related receptor α (ERRα) on bone. It states that ERRα, which is a member of the nuclear hormone receptor superfamily, acts as a transcription factor and is expressed in ossification zones during development. The study found that in female mice, ERRαKO bones do not age and are resistant to bone loss induced by age or estrogen withdrawal, while no phenotype was observed in the bones of male ERRαKO mice.


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