Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-Deficiency

November 2009
PLoS ONE;2009, Vol. 4 Issue 11, p1
Academic Journal
The article focuses on a study on knock-out mice to examine the in vivo effect of estrogen-receptor related receptor α (ERRα) on bone. It states that ERRα, which is a member of the nuclear hormone receptor superfamily, acts as a transcription factor and is expressed in ossification zones during development. The study found that in female mice, ERRαKO bones do not age and are resistant to bone loss induced by age or estrogen withdrawal, while no phenotype was observed in the bones of male ERRαKO mice.


Related Articles

  • Inhibition of the Progesterone Nuclear Receptor during the Bone Linear Growth Phase Increases Peak Bone Mass in Female Mice. Yao, Wei; Dai, Weiwei; Shahnazari, Mohammad; Pham, Aaron; Chen, Zhiqiang; Chen, Haiyan; Guan, Min; Lane, Nancy E. // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Augmentation of the peak bone mass (PBM) may be one of the most effective interventions to reduce the risk of developing osteoporosis later in life; however treatments to augment PBM are currently limited. Our study evaluated whether a greater PBM could be achieved either in the progesterone...

  • The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Gerhart-Hines, Zachary; Feng, Dan; Emmett, Matthew J.; Everett, Logan J.; Loro, Emanuele; Briggs, Erika R.; Bugge, Anne; Hou, Catherine; Ferrara, Christine; Seale, Patrick; Pryma, Daniel A.; Khurana, Tejvir S.; Lazar, Mitchell A. // Nature;11/21/2013, Vol. 503 Issue 7476, p410 

    Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure. However, the mechanism responsible for coordinating daily body...

  • Estrogen receptor subtypes localization shifts in cultured mouse ovarian follicles. Lenie, Sandy; Smitz, Johan // Histochemistry & Cell Biology;Jun2008, Vol. 129 Issue 6, p827 

    Estrogens play an important role in the growth, differentiation, and function of female reproductive tissues. Estrogen signals through estrogen receptors (ERs), members of the nuclear receptor superfamily. The two major forms, ERα and ERβ, are expressed in the mouse ovary, where ERβ is...

  • Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver. Sueyoshi, Tatsuya; Green, William D.; Vinal, Kellie; Woodrum, Tyler S.; Moore, Rick; Negishi, Masahiko // PLoS ONE;2011, Vol. 6 Issue 6, p1 

    Constituent chemicals in garlic extract are known to induce phase I and phase II enzymes in rodent livers. Here we have utilized Car+/+ and Car2/2 mice to demonstrate that the nuclear xenobiotic receptor CAR regulated the induction of the estrogen sulfotransferase Sult1e1 gene by diallyl sulfide...

  • Genomic Convergence among ERRa, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs. Dufour, Catherine R.; Levasseur, Marie-Pier; Nguyen Hoai Huong Pham; Eichner, Lillian J.; Wilson, Brian J.; Charest-Marcotte, Alexis; Duguay, David; Poirier-Héon, Jean-François; Cermakian, Nicolas; Giguère, Vincent // PLoS Genetics;Jun2011, Vol. 7 Issue 6, Special section p1 

    Metabolic homeostasis and circadian rhythms are closely intertwined biological processes. Nuclear receptors, as sensors of hormonal and nutrient status, are actively implicated in maintaining this physiological relationship. Although the orphan nuclear receptor estrogen-related receptor a (ERRa,...

  • Peroxisome Proliferator-Activated Receptor-γ in Amyotrophic Lateral Sclerosis and Huntington's Disease. Kiaei, Mahmoud // PPAR Research;2008, Special section p1 

    Amyotrophic lateral sclerosis (ALS) is a debilitating and one of the most common adult-onset neurodegenerative diseases with the prevalence of about 5 per 100 000 individuals. It results in the progressive loss of upper and lower motor neurons and leads to gradual muscle weakening ultimately...

  • Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Jianming Xu; Wu, Ray-Chang; O'Malley, Bert W.; Xu, Jianming // Nature Reviews Cancer;Sep2009, Vol. 9 Issue 9, p615 

    The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRCgenes are subject to...

  • Regulation of IκBα expression involves both NF-#x03BA;B and the MAP kinase signaling pathways. Ning Zhang; Ahsan, Muhammad H.; Lingyun Zhu; Sambucetti, Lidia C.; Purchio, Anthony F.; West, David B. // Journal of Inflammation;2005, Vol. 2, p10 

    IκBα is an inhibitor of the nuclear transcription factor NF-κB. Binding of IκBα to NF-κB inactivates the transcriptional activity of NF-κB. Expression of IκBα itself is regulated by NF-κB, which provides auto-regulation of this signaling pathway. Here we present a...

  • A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis. Kan He; Qishan Wang; Yumei Yang; Minghui Wang; Yuchun Pan // PPAR Research;2011, Special section p1 

    Gene expression profiling of PPARα has been used in several studies, but fewer studies went further to identify the tissue-specific pathways or genes involved in PPARα activation in genome-wide. Here, we employed and applied gene set enrichment analysis to two microarray datasets both...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics