Cytokine Levels Correlate with Immune Cell Infiltration after Anti-VEGF Therapy in Preclinical Mouse Models of Breast Cancer

November 2009
PLoS ONE;2009, Vol. 4 Issue 11, p1
Academic Journal
The article offers information on a study related to immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. It is stated that the effect of blocking VEGF activity in solid tumors extends beyond inhibition of angiogenesis. However, no studies have compared the effectiveness of mechanistically different anti-VEGF inhibitors with respect to changes in tumor growth and alterations in the tumor microenvironment. The study evaluated the cytokine levels using ELISA and electrochemiluminescence.


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