Non-occupational exposure to asbestos and malignant mesothelioma in the Italian National Registry of Mesotheliomas

Mirabelli, Dario; Cavone, Domenica; Merler, Enzo; Gennaro, Valerio; Romanelli, Antonio; Mensi, Carolina; Chellini, Elisabetta; Nicita, Carmela; Marinaccio, Alessandro; Magnani, Corrado; Musti, Marina
November 2010
Occupational & Environmental Medicine;Nov2010, Vol. 67 Issue 11, p10
Academic Journal
Background Malignant mesotheliomas are strictly related to asbestos, but in a proportion of cases no exposure can be recalled. Published estimates of this proportion have important variations. Historical and geographical differences in the fraction of cancer due to any given exposure are to be expected, but incomplete identification of non-occupational exposures may have played a role. Methods To assess the role of non-occupational exposures in causing malignant mesotheliomas in Italy, the exposures of cases registered by the national mesothelioma registry (ReNaM) were examined. ReNaM started in 1993 in five regions and currently covers 98% of the Italian population. Information on occupational and non-occupational exposures of cases is collected whenever possible. Results From 1993 to 2001 ReNaM registered 5173 malignant mesothelioma cases, and exposures were assessed in 3552 of them. 144 and 150 cases with exposures limited to environmental (living in the neighbourhood of an industrial or natural source of asbestos) or familial (living with a person occupationally exposed to asbestos) circumstances, respectively, were identified, accounting for 8.3% of all cases. Conclusions Geographical variations in the proportion of cases due to non-occupational exposures may be explained by the past distribution of asbestos-using industries.


Related Articles

  • Malignant Mesothelioma Resistance to Apoptosis: Recent Discoveries and their Implication for Effective Therapeutic Strategies. Villanova, F.; Procopio, A.; Rippo, M. R. // Current Medicinal Chemistry;2008, Vol. 15 Issue 7, p631 

    Malignant Mesothelioma is an aggressive and fatal type of tumor. The incidence of mesothelioma has increased in the past 30 years and is now common as male cancers of the liver, bone and bladder, especially in Europe and Australia. The main risk factor is asbestos exposure even if other...

  • New diagnostic and therapeutic avenues for mesothelioma. Paracha, Usman Zafar; Hayat, Khezar; Ali, Muhammad; Qadir, Muhammad Imran // Pakistan Journal of Pharmaceutical Sciences;Jul2015, Vol. 28 Issue 4, p1425 

    Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by asbestos exposure or exposure to nanofibers. Median survival is less than one year in the mesothelioma patients. Due to its severity, there is a dire necessity to find out new diagnostic and...

  • Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis. Tomasetti, Marco; Amati, Monica; Nocchi, Linda; Saccucci, Franca; Strafella, Elisabetta; Staffolani, Sara; Tarquini, Lucia Miria; Carbonari, Damiano; Alleva, Renata; Borghi, Battista; Neuzil, Jiri; Bracci, Massimo; Santarelli, Lory // Mutagenesis;Sep2011, Vol. 26 Issue 5, p585 

    Asbestos is known to induce malignant mesothelioma (MM) and other asbestos-related diseases. It is directly genotoxic by inducing DNA strand breaks and cytotoxic by promoting apoptosis in lung target cells. Poly(ADP-ribose) polymerase-1 (PARP1) is a nuclear zinc-finger protein with a function as...

  • The exploitation and environmental legacy of amphibole asbestos: a late 20th century overview Gibbons, Wes // Environmental Geochemistry & Health;Dec1998, Vol. 20 Issue 4, p213 

    The risk to human health associated with the inhalation of amphiboleasbestos has become devastatingly apparent this century. The most commonly utilised asbestiform amphiboles, crocidolite (blue asbestos) and amosite (brown asbestos), are implicated in a variety of diseases related to cell damage...

  • Asbestos exposure and laryngeal cancer: Is there an association? Ahmad, Sidrah M.; Sataloff, Robert T. // ENT: Ear, Nose & Throat Journal;Oct2009, Vol. 88 Issue 10, p1140 

    The author examines the link between exposure to asbestos and laryngeal cancer. He cites known risk factors for such a type of cancer, including cigarette smoking. He notes the failure of studies to show a convincing association between the two events after adjusting for smoking and alcohol use....

  • Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile. Loomis, Dana; Dement, John; Richardson, David; Wolf, Susanne // Occupational & Environmental Medicine;Sep2010, Vol. 67 Issue 9, p580 

    Objectives To estimate exposures to asbestos fibres of specific sizes among asbestos textile manufacturing workers exposed to chrysotile using data from transmission electron microscopy (TEM) and to evaluate the extent to which the risk of lung cancer varies with fibre length and diameter....

  • Dangerous When in Power. Olson, Walter // Reason;Mar2007, Vol. 38 Issue 10, p33 

    The article reflects on whether the U.S. government protects its people from hazardous products or it puts them in harm's way. It cites that asbestos exposure has been considered a health calamity, which has caused much death and disability among exposed workers. It asserts that the government...

  • Assessment of Environmental and Domestic Exposure to Tremolite in New Caledonia. Luce, Dani�le; Billon-Galland, Marie-Annick; Bugel, Isabelle; Goldberg, Paquerette; Salomon, Christine; F�votte, Jo�lle; Goldberg, Marcel // Archives of Environmental Health;Feb2004, Vol. 59 Issue 2, p91 

    The article presents the findings of a study that characterized exposure to asbestos in the population of New Caledonia, an area where a high mesothelioma incidence was found to be associated with the use of a tremolite-containing whitewash on dwellings. The researchers collected airborne...

  • A framework for using epidemiological data for risk assessment. Swaen, G. M. H // Human & Experimental Toxicology;Mar2006, Vol. 25 Issue 3, p147 

    Data on health effects from human exposure to chemicals provide the most direct information for risk assessment. Despite their clear relevance for risk assessment and despite the frequently made statements by regulatory bodies to use epidemiological data whenever deemed appropriate, they are not...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics