TITLE

Executive function modifies the relationship between occupational lead exposure and complex figure test performance

AUTHOR(S)
Walsh, Karin S.; Celio, Mark A.; Vaughan, Christopher G.; Lindgren, Karen N.; Bleecker, Margit L.
PUB. DATE
October 2010
SOURCE
Occupational & Environmental Medicine;Oct2010, Vol. 67 Issue 10, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives To determine if chronic lead exposure is associated with non-verbal memory performance and if this association is affected by organisation strategies, a component of executive functions. Methods We administered the Rey-Osterrieth Complex Figure (ROCF) test, both copy (ROCF-C) and 30-min delayed recall (ROCF-DR), to 358 current lead smelter workers with a mean (SD) age of 41 (9.1) years, education of 11 (2.7) years, and working lifetime-weighted average blood lead (TWA) of 39 (12.0) µg/dl. Copy and delay organisation scores, surrogates for executive functions, were developed for ROCF-C and ROCF-DR. We used multiple regression analyses to examine the relationship between TWA and ROCF performance, organisational scores, and the interaction of organisational scores and TWA after adjusting for relevant covariates. Results Organisational scores, while not associated with years of education, were significantly correlated with ROCF-C and ROCF-DR performance. We found a significant relationship between TWA and ROCF-DR but not with ROCF-C performance. The interactions of TWA by copy organisation and TWA by delay organisation were significant for ROCF-DR with a significant dose-effect relationship only in participants with lower organisational scores. Conclusions Chronic lead exposure was significantly associated with complex figure test delayed recall but not copy performance. Organisational strategies, a component of executive functions, served as effect modifiers of the relationship between lead exposure and non-verbal memory. With increasing TWA exposure workers with good organisational strategies maintained performance on the complex figure test while workers with poor organisational strategies demonstrated decreasing performance.
ACCESSION #
56089473

 

Related Articles

  • Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson's Disease. Coon, Steven; Stark, Azadeh; Peterson, Edward; Gloi, Aime; Kortsha, Gene; Pounds, Joel; Chettle, David; Gorell, Jay // Environmental Health Perspectives;Dec2006, Vol. 114 Issue 12, p1872 

    BACKGROUND: Several epidemiologic studies have suggested an association between Parkinson's disease (PD) and exposure to heavy metals using subjective exposure measurements. OBJECTIVES: We investigated the association between objective chronic occupational lead exposure and the risk of PD....

  • Effect of exposure to lead on postural control in workers. Ratzon, N.; Froom, P.; Leikin, E.; Kristal-Boneh, E.; Ribak, J. // Occupational & Environmental Medicine;Mar2000, Vol. 57 Issue 3, p201 

    Focuses on the effect of exposure to lead on postural control in workers. Measurement of postural control; Impact of lead exposure on workers.

  • Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1. Lee, Hanki; Suh, Joo-Won // Journal of Industrial Microbiology & Biotechnology;Mar2016, Vol. 43 Issue 2/3, p205 

    Tuberculosis (TB) is a serious and potentially fatal disease caused by Mycobacterium tuberculosis ( M. tb). The occurrence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) M. tb is a significant public health concern because most of the anti-TB drugs that have been in use for...

  • Occupational Exposure of Workers at Gas Station to Inorganic Lead. Cabaravdic, Mirsad; Mijanovic, Mirjana; Kusturica, Jasna; Cabaravdic, Amra // Medicinski Arhiv;2010, Vol. 64 Issue 2, p107 

    Exposure to the lead is public health problem and threat to environment with proven harmful impact on human, including industrial workers and general population. Harmful impacts of exposition to nervous, endocrine, hematological, cardiovascular, immune and reproductive system to the lead are...

  • Surveillance of Occupational Lead Exposure in New Jersey: 1986 to 1989. Tepper, Allison // American Journal of Public Health;Feb1992, Vol. 82 Issue 2, p275 

    QBetween January 1986 and June 1989, 1916 New Jersey workers were identified through a surveillance system for occupational lead exposures. The average annual proportion of workers with a blood lead level above 2.42 μmol/L was 12%. Industries with the highest proportion at workers with blood...

  • Chasing the lead. Waldron, H. A. // British Medical Journal (Clinical Research Edition);8/10/1985, Vol. 291 Issue 6492, p366 

    The article focuses on the harmful physiological effects of lead. It discusses the inhalation and ingestion risks in occupational lead poisoning. It cites a case in an Arab village on the West Bank wherein flour produced in mills were determined as the cause of lead poisoning. According to the...

  • Adult Blood Lead Reporting in New York State, 1994—2006. Gelberg, Kitty H.; Fletcher, Alicia // Public Health Reports;Jan/Feb2010, Vol. 125 Issue 1, p103 

    Objectives. Laboratories that test New York State (NYS) employees and adult residents for lead exposure are required to report blood lead test results to the NYS Department of Health's Heavy Metals Registry. This registry is used tc monitor exposures and to identify new high-risk occupational...

  • Lead exposure among five distinct occupational groups: A comparative study. Gharaibeh, Mohammad Younis; Hasan Alzoubi, Karem; Falah Khabour, Omar; Saleh Khader, Yousef; Gharaibeh, Mamoun Abd allah; Khalid Matarneh, Sulaiman // Pakistan Journal of Pharmaceutical Sciences;Jan2014, Vol. 27 Issue 1, p39 

    This study was conducted to evaluate blood lead concentration among five selected occupational groups. The five groups were: hospital health workers, shop workers, taxi drivers, automobiles mechanics, and wood workers. The groups did not significantly differ among each other in the average of...

  • A study on lead toxicity among the workers in an unorganized sector of lead-acid battery industry. Sarathy Naidana, Partha; Chakravarthi Burra, Kalyan; Peesapati, Seetharamacharyulu // Al Ameen Journal of Medical Sciences;Oct-Dec2013, Vol. 6 Issue 4, p350 

    Aims of the study: (1)-To study various manifestations of lead toxicity at different levels of exposure among the Lead-Acid battery workers and (2)-To study various factors contributing to the toxicity of lead among the workers. Results: High amounts of lead were detected in the blood samples of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics