TITLE

Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?

AUTHOR(S)
Gani, Osman A. B. S. M.
PUB. DATE
January 2008
SOURCE
Cardiovascular Diabetology;2008, Vol. 7, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Peroxisome proliferator-activated receptors (PPARa, PPAR?, and PPARd) are physiological sensors for glucose and lipid homeostasis. They are also the targets of synthetic drugs; such as fibrates as PPARa agonists which lower lipid level, and glitazones as PPAR? agonists which lower glucose level. As diabetes and metabolic diseases are often associated with high blood glucose and lipid levels, drugs that activate both PPARa/? would be a logical approach. But synthetically developed PPARa/? dual agonists and glitazones are showing side effects such as weight gain and edema. Therefore, natural compounds and their close derivatives are focused as future drugs against metabolic diseases. Presentation of hypothesis: Docosahexaenoic acid and eicosapentaenoic acid, which are the fatty acids abundant in fish oil, are traditionally used against metabolic diseases. These fatty acids act as PPAR agonists that transcript the genes involved in glucose and lipid homeostasis. Present hypothesis suggests that the derivatives of these fatty acids are stronger PPAR agonists than the parent compounds. X-ray structures of PPARs indicate that a or � derivatives of fatty acids would fit into PPARa/? binding cavity. Therefore, the derivatives will exhibit stronger affinities and activities than the parent compounds. Testing of the hypothesis: Ligand binding assays and gene transactivation assays should be performed to test the hypothesis. Fluorescence-based methods are advantageous in binding assays, because they were found more suitable for fatty acid binding assays. In transactivation assays, care should be taken to remove contaminants from recombinant proteins. Implications of the hypothesis: Present hypothesis is framed on the basis of molecular structure of natural PPAR agonists. Small structural changes in the molecular structure of fatty acids have a great influence on activating different PPARs. Therefore, this hypothesis bridges the concept of natural PPAR agonists and the use of structural information in designing new drugs against diabetes and metabolic syndrome. The derivatives may also be used as anti-inflammatory and anticancer agents.
ACCESSION #
55716399

 

Related Articles

  • More research needed on krill oil -- another source for omega-3s.  // Primary Care Optometry News;Apr2013, Vol. 18 Issue 4, p15 

    In this article, the author offers information on krill oil, a type of fish oil that is a source for omega-3 fatty acids.

  • Mood Food. Barbor, Cary // Psychology Today;Jan/Feb2001, Vol. 34 Issue 1, p22 

    Presents an overview of a research which showed that fish oil's omega-3 fatty acids may improve mood and mental health. Results of the research; Effect of fatty acids from fish oil on the communication channels in the brain.

  • omega-3s, new & improved. Brechka, Nicole // Better Nutrition;Mar2013, Vol. 75 Issue 3, p18 

    The article presents information on several products which contain essential fatty acids, including Carlson Labs Salmon Oil Complete supplements, Dr. in the Kitchen Flackers snack crackers and Coromega, Big Squeeze drink pouches.

  • Less Fishy Fish Oil.  // Prevention;Aug2012, Vol. 64 Issue 8, p12 

    The article offers tips for taking fish oil from omega-3 fatty acids such as mixing it with yogurt, taking the pills before and not after a meal, stashing them in the freezer or picking up a lemon-flavored brand.

  • Fats & oils.  // Food Manufacture;Jan1996, Vol. 71 Issue 1, p16 

    Presents information on the benefits of Omega-3 polyunsaturated fatty acids (PUFA) in the diet. Importance of refining technology; Information on Diet and Reinfarction Trial (DART); Benefits of Omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); Health benefits of...

  • ASK THE WELLNESS DOC. Lamm, Steven // Best Life;Jun2008, Vol. 5 Issue 5, p72 

    The article provides an answer to a question of whether krill oil is a better source of omega-3s than fish oil.

  • Fish Oil May Help Diabetic Hearts.  // Life Extension;Sep2003, Vol. 9 Issue 9, p17 

    Reports on the research on the consumption of fish oil to reduce the risk of coronary heart diseases among persons with diabetes in the U.S. Presence of omega-3 fatty acids in fish oil; Prevention for the development of blood clots; Avoidance for fatal irregular heart rhythm.

  • CALGENEX UNVEILS OMEGANOL FOR CHOLESTEROL/TRIGLYCERIDES.  // Biotech Business;Nov2006, Vol. 19 Issue 11, p4 

    The article provides information on Omeganolâ„¢, introduced by Calgenex Corp. in Tampa, Florida. Omeganolâ„¢ is a natural product for management of cholesterol and triglyceride which contains concentration of omega-3 fish oils and fractions from palm fruit and annatto flower. Overview of...

  • The fish oil phenomenon.  // Dairy Industries International;Nov2002, Vol. 67 Issue 11, p18 

    Reports the major problem on the application of Omega-3 fish oil in dairy products in Great Britain. Importance of eliminating air from products throughout the processing; Accounts on the knowledge of double bonds in the fatty acids; Ways of using Omega-3 in dairy products.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics