TITLE

Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity

AUTHOR(S)
S�ez, Mar�a E.; Grilo, Antonio; Mor�n, Francisco J.; Manzano, Luis; Mart�nez-Larrad, Mar�a T.; Gonz�lez-P�rez, Antonio; Serrano-Hernando, Javier; Ruiz, Agust�n; Ram�rez-Lorca, Reposo; Serrano-R�os, Manuel
PUB. DATE
January 2008
SOURCE
Cardiovascular Diabetology;2008, Vol. 7, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Context: Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. Objective: To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Design: Cross-sectional, genetic association study and gene-gene interaction analysis. Subjects: The study sample comprise 1953 individuals, 725 obese (defined as body mass index = 30) and 1228 non obese subjects. Results: In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%. Conclusion: Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
ACCESSION #
55716382

 

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