Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform

Ogawa, Osamu; Hiraoka, Kiyoko; Watanabe, Takahiro; Kinoshita, Junichiro; Kawasumi, Masahiko; Yoshii, Hidenori; Kawamori, Ryuzo
January 2008
Cardiovascular Diabetology;2008, Vol. 7, p1
Academic Journal
Background: To investigate the clinical differences between pulse wave velocity and augmentation index in diabetic retinopathy. Methods: The subjects were 201 patients with type 2 diabetes. These subjects were measured for both augmentation index (AI) and brachial-ankle pulse wave velocity (baPWV) by a pulse wave analyzer. The relationships between AI, baPWV, and diabetic retinopathy were examined. Results: BaPWV was significantly higher in patients with diabetic retinopathy than in individuals without the disease. (20.13 ± 3.66 vs.17.14 ± 3.60 m/s p < 0.001) AI was higher in patients with diabetic retinopathy, but not significantly. (19.5 ± 15.2 vs. 14.8 ± 20.5% p = 0.14) The association between baPWV and diabetic retinopathy remained statistically significant after adjustment. (Odds ratio: 1.21 Per m/s, 95% confidence interval: 1.07-1.37) On the other hand, the association between AI and diabetic retinopathy was not statistically significant. (Odds ratio: 1.01 Per %, 95% confidence interval: 0.98-1.03) Conclusion: BaPWV is associated with diabetic retinopathy, but AI is not. The clinical significance appears to be different between PWV and AI in patients with diabetes.


Related Articles

  • Plasma Plasminogen Activator Inhibitor-1 Is Associated with End-Stage Proliferative Diabetic Retinopathy in the Northern Chinese Han Population. Ze-Long Zhong; Song Chen // Experimental Diabetes Research;2012, Special section p1 

    Objective. To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population. Methods. We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62...

  • The Nerve Trumps the Cornea. Fanelli, James L. // Review of Optometry;10/15/2009 Part 1 of 2, Vol. 146 Issue 10, p91 

    The article presents a study of a 71-year old white male for a diabetic retinal evaluation. In 1997, the patient was first diagnosed of having a type 2 diabetes, and was given medications for his maintenance. Diagnostic examinations of the patient includes slit lamp examinations, measurement of...

  • The North Jutland Counly Diabetic Retinopathy Study: population characteristics. Knudsen, L. L.; Lervang, H. -H.; Lundbye-Christensen, S.; Gorst-Rasmussen, A. // British Journal of Ophthalmology;Nov2006, Vol. 90 Issue 11, p1404 

    Background: Several population-based studies have reported blood glucose levels and blood pressure to be risk factors for the development of diabetic retinopathy. These studies were initiated more than two decades ago and may therefore reflect the treatment and population composition of a...

  • Can the Retinal Screening Interval Be Safely Increased to 2 Years for Type 2 Diabetic Patients Without Retinopathy? Chalk, Daniel; Pitt, Martin; Vaidya, Bijay; Stein, Ken // Diabetes Care;Aug2012, Vol. 35 Issue 8, p1663 

    OBJECTIVE--In the U.K., people with diabetes are typically screened for retinopathy annually. However, diabetic retinopathy sometimes has a slow progression rate. We developed a simulation model to predict the likely impact of screening patients with type 2 diabetes, who have not been diagnosed...

  • Blue clue: diabetes. Harrar, Sarí N. // Prevention;Nov2004, Vol. 56 Issue 11, p38 

    Discusses how washed-out color vision might be a warning sign of type 2 diabetes. Vision checks that revealed that 32% of people with diabetic retinopathy had trouble seeing blues and yellows; Importance of early detection.

  • Can Self-Rated Health Scores Be Used for Risk Prediction in Patients With Type 2 Diabetes? Hayes, Alison J.; Clarke, Philip M.; Glasziou, Paul G.; Simes, R. John; Drury, Paul L.; Keech, Anthony C. // Diabetes Care;Apr2008, Vol. 31 Issue 4, p795 

    OBJECTIVE -- To investigate whether self-rated health profiles compiled using the EuroQol group's visual analog scale (EQ VAS) are independent predictors of vascular events and major complications in people with type 2 diabetes after controlling for standard clinical risk factors. RESEARCH...

  • Rosiglitazone.  // Reactions Weekly;6/14/2008, Issue 1206, p27 

    The article describes the case of a man with type 2 diabetes mellitus who developed retinal oedema while being treated with rosiglitazone. Rosiglitazone was discontinued and the man's peripheral oedema had lessened. Visual acuity in his left eye improved, retinal oedema resolved and no further...

  • The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patients with type 2 diabetes. Yuxin Xu; Zhengxuan Jiang; Jinhai Huang; Qianli Meng; Coh, Paul; Liming Tao // British Journal of Ophthalmology;Sep2015, Vol. 99 Issue 9, p1301 

    Purpose Diabetic retinopathy (DR) is one of the secondary microvascular complications of type 2 diabetes mellitus. Persistent inflammation and impaired neovascularisation may be important contributors to the development of DR. A recent study showed that toll-like receptor 4 (TLR4) polymorphisms...

  • Relationship Between Retinal Blood Flow and Renal Function in Patients With Type 2 Diabetes and Chronic Kidney Disease. NAGAOKA, TAIJI; YOSHIDA, AKITOSHI // Diabetes Care;Apr20123, Vol. 36 Issue 4, p957 

    OBJECTIVE--To study the relationship between retinal microcirculation and renal function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS--Using a laser Doppler velocimetry system, we obtained the retinal blood flow (RBF) values by simultaneously measuring the retinal vessel...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics