TITLE

An Analysis of Sestamibi-Positive versus -Negative Patients with Primary Hyperparathyroidism

AUTHOR(S)
Parel, Robert J.; Bolton, John S.; Fuhrman, George M.
PUB. DATE
November 2001
SOURCE
American Surgeon;Nov2001, Vol. 67 Issue 11, p1101
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We performed this study to evaluate two patient groups with primary hyperparathyroidism depending on whether their abnormal gland(s) could be preoperatively imaged with sestamibi. Patients with primary hyperparathyroidism evaluated by preoperative sestamibi examination from January 1999 to June 2000 were divided into two groups depending on the ability of sestamibi to localize their disease. Records were reviewed to determine pre- and postoperative biochemical data, weight of the excised glands, and total operating room time. When the sestamibi imaging was positive a minimally invasive parathyroidectomy was performed; however, when sestamibi scanning was negative patients underwent a formal bilateral neck exploration. All 40 patients in the sestamibi-positive group and 17 of 18 patients in th sestamibi-negative group were cured of their primary hyperparathyroidism as a result of surgery. Sestamibi scanning with a minimally invasive parathyroidectomy shortens operating room time and is most effective when adenomas are large. The results of this study suggest that strategies to preoperatively increase the activity of adenomas may improve the sensitivity of sestamibi scan localization of parathyroid adenomas.
ACCESSION #
5562964

 

Related Articles

  • Impact of conventional and three-dimensional thallium--technetium scans on surgery for primary hyperparathyroidism. Jenkins, B. J.; Newell, M. S.; Goode, A. W.; Boucher, B. J.; Monson, J. P.; Brown, C. L. // Journal of the Royal Society of Medicine;Jul1990, Vol. 83 Issue 7, p427 

    Twenty-nine patients with primary hyperparathyroidism underwent double-tracer subtraction scanning after injection of 201Tl as thallous chloride for thyroid and parathyroid images followed by 99mtechnetium as sodium pertechnetate for thyroid images prior to surgical exploration of the neck. The...

  • Clinical role of [sup 99m] TcO[sub 4] /MIBI scan, ultrasound and intra-operative gamma probe in the performance of unilateral and minimally invasive surgery in primary hyperparathyroidism. Casara, Dario; Rubello, Domenico; Pelizzo, Maria Rosa; Shapiro, Brahm // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 9, p1351 

    The main purposes of this study were: (a) to investigate the efficacy of an imaging protocol based on the combination of [sup 99m] TcO[sub 4] /MIBI scintigraphy and neck ultrasound (US) in selecting patients with primary hyperparathyroidism (HPT) for unilateral neck exploration, and (b) to help...

  • Primary hyperparathyroidism in pregnancy: a case series and review. Truong, M. T.; Lalakea, M. L.; Robbins, P.; Friduss, M. // Obstetric Medicine (1753-495X);Jun2009, Vol. 2 Issue 2, p88 

    The article offers information on the study regarding the prevalence of primary hyperparathyroidism in pregnant women, which gives emphasis on the relative benefits of surgery.

  • Surgical anatomy of the parathyroid glands in secondary hyperparathyroidism. Butterworth, P.C.; Nicholson, M.L. // Journal of the Royal College of Surgeons of Edinburgh;Aug98, Vol. 43 Issue 4, p372 

    Examines the surgical anatomy of the parathyroid glands in secondary hyperparathyroidism in Great Britain. Descriptions of parathyroid anatomy based on studies of normal glands; Presentation of the details parathyroid anatomy of patients; Comparisons on the anatomical locations in series of...

  • Cost utility of routine imaging with Tc-99m-sestamibi in... Wei, John P.; Burke, George J. // American Surgeon;Dec1997, Vol. 63 Issue 12, p1097 

    Analyzes the cost effectiveness of Tc-99m-sestamibi radiologic test before initial surgery for primary hyperparathyroidism. Clinical procedures used for the patients in the study; Statistical analysis of the data; Discussion on the research findings; Conclusions; Commentaries and questions of...

  • Initial cervical exploration for parathyroidectomy is not benefited by preoperative localization... Roe, S. Michael; Brown, Preston W.; Pate, Linda M.; Summitt, J. Blair; Ciraulo, David L.; Burns, R. Phillip // American Surgeon;Jun1998, Vol. 64 Issue 6, p503 

    Reports on the outcome of a six-year review of a surgeon's experience to determine whether preoperative localization studies are beneficial to the initial surgical management of patients with primary hyperparathyroidism (PHPT). Patient costs of localization studies; Preoperative localization...

  • Initial Neck Exploration for Untreated Hyperparathyroidism. Martin, II, Robert C.G.; Greenwell, Darren; Flynn, Michael B. // American Surgeon;Mar2000, Vol. 66 Issue 3, p269 

    This study represents the experience of the Department of Surgery at the University of Louisville over a 21-year interval. Many aspects of surgical management of hyperparathyroidism have changed over the last 2 decades; controversies regarding the extent of exploration and the value of...

  • 5th biennual congress of the European Society of Endocrine Surgeons (ESES) Gothenburg Sweden, May 24-26, 2012.  // Langenbeck's Archives of Surgery;Jun2012, Vol. 397 Issue 5, p843 

    The article presents abstracts on medical topics which include morbidity followed by thyroid surgery, random trial of hemithyroidectomy versus Dunhill for asymmetrical goiter, and improvement in bone mineral density after operation for primary hyperparathyroidism.

  • Minimally invasive parathyroidectomy for primary hyperparathyroidism: Decreasing operative time... Norman, James; Chheda, Hemant; Farrell, Connie // American Surgeon;May1998, Vol. 64 Issue 5, p391 

    Evaluates the efficacy and safety of unilateral neck exploration for patients with hyperparathyroidism (HPTH) and adenoma. Results of the sestamibi scans of the patients; Anesthetic technique applied; Decrease of the total operative time; Successful application of the minimally invasive...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics