TITLE

Rate and Predictors of Early/Missed Colorectal Cancers After Colonoscopy in Manitoba: A Population-Based Study

AUTHOR(S)
Singh, Harminder; Nugent, Zoann; Demers, Alain A; Bernstein, Charles N
PUB. DATE
December 2010
SOURCE
American Journal of Gastroenterology;Dec2010, Vol. 105 Issue 12, p2588
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES:Many of the colorectal cancers (CRCs) diagnosed within 3 years after a colonoscopy are likely because of lesions missed on the initial colonoscopy. In this population-based study, we investigated the rate and predictors of CRCs diagnosed within 3 years of a colonoscopy.METHODS:We identified individuals 50-80 years of age diagnosed with CRC between 1992 and 2008 from the provincewide Manitoba Cancer Registry. Performance of colonoscopy and history of co-morbidities was determined by linkage to the provincial universal health care insurance provider's physician billing claims and hospital discharges databases. CRCs diagnosed within 6 months of a colonoscopy were categorized as detected CRCs and those 6-36 months after a colonoscopy as early/missed CRCs. Logistic regression analysis was performed to identify the patient, endoscopist, colonoscopy, and CRC factors associated with early/missed CRCs.RESULTS:Of the 4,883 CRCs included in the study, 388 (7.9%) were early/missed CRCs, with a range of 4.5% of rectum/rectosigmoid cancers in men to 14.4% of transverse colon/splenic flexure cancers in women. Independent risk factors associated with early/missed CRCs included prior colonoscopy, performance of index colonoscopy by family physicians, recent year of CRC diagnosis, and proximal site of CRC.CONCLUSIONS:This study suggests that approximately 1 in 13 CRCs may be an early/missed CRC, diagnosed after an index colonoscopy in usual clinical practice. Women are more likely to have early/missed CRC. It is unclear if this relates to differences in procedure difficulty, bowel preparation issues, or tumor biology between men and women.
ACCESSION #
55595885

 

Related Articles

  • Changes on the disease pattern of primary colorectal cancers in Southern China: a retrospective study of 20 years. Shenghong Zhang; Yi Cui; Zijin Weng; Xiaorong Gong; Minhu Chen; Bihui Zhong // International Journal of Colorectal Disease;Aug2009, Vol. 24 Issue 8, p943 

    Some changes on the disease pattern of colorectal cancer (CRC) have occurred in some Asian countries recently. However, nothing is known about it in China lately. The present study is to determine whether there are any changes on the disease pattern of CRC in Southern China. Data were collected...

  • Extracolonic findings at virtual colonoscopy: an important consideration in asymptomatic colorectal cancer screening. Kimberly, James R.; Phillips, Kim C.; Santago, Pete; Perumpillichira, James; Bechtold, Robert; Pineau, Benoit; Vining, David; Bloomfeld, Richard S. // JGIM: Journal of General Internal Medicine;Jan2009, Vol. 24 Issue 1, p69 

    Background: Virtual colonoscopy has been evaluated for use as a colorectal cancer screening tool, and in prior studies, it has been estimated that the evaluation of extra-colonic findings adds $28-$34 per patient studied.Methods: As an ancillary study to a prospective...

  • Serrated polyps detected during screening colonoscopies. Świątkowski, Maciej; Meder, Agnieszka; Sobczyński, Lesław; Koza, Jarosław; Szamocka, Małgorzata; Brudny, Janina; Korenkiewicz, Jadwiga // Contemporary Oncology / Wspolczesna Onkologia;2014, Vol. 18 Issue 1, p54 

    Aim of the study: It is estimated that between 15% and 35% of sporadic colorectal cancers (CRC) developing from adenomas come from serrated polyps. Currently, the most effective method used to prevent CRC is the removal of adenomas, including serrated polyps, during colonoscopy. The aim of this...

  • Response: Re: Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study. BRENNER, HERMANN; HOFFMEISTER, MICHAEL; ARNDT, VOLKER; HAUG, ULRIKE // JNCI: Journal of the National Cancer Institute;Jul2010, Vol. 102 Issue 13, p990 

    A response by Hermann Brenner et al, to a letter to the editor about their article "Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study" is presented.

  • Colonoscopy adenoma detection rate predicted risk for interval colorectal cancer. Cona, Christen; Harris, Jason; Southall, Jennifer // Hem/Onc Today;6/10/2010, Vol. 11 Issue 11, p25 

    The article discusses research published in a 2010 issue of the "New England Journal of Medicine," which found that link between colonoscopy adenoma detection rate and risk for interval colorectal cancer.

  • The association between cecal insertion time and colorectal neoplasm detection. Moon Hee Yang; Juhee Cho; Sanjay Rampal; Eun Kyung Choi; Yoon-Ho Choi; Jun Haeng Lee; Young-Ho Kim; Dong Kyung Chang; Poong-Lyul Rhee; Kim, Jae J.; Guallar, Eliseo; Jong Chul Rhee; Hee Jung Son // BMC Gastroenterology;2013, Vol. 13 Issue 1, p1 

    Background: Information on the impact of cecal insertion time on colorectal neoplasm detection is limited. Our objective was to determine the association between cecal insertion time and colorectal neoplasm detection rate in colonoscopy screening. Methods: We performed a cross-sectional study of...

  • Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Baba, Yoshifumi; Huttenhower, Curtis; Nosho, Katsuhiko; Tanaka, Noriko; Shima, Kaori; Hazra, Aditi; Schernhammer, Eva S.; Hunter, David J.; Giovannucci, Edward L.; Fuchs, Charles S.; Shuji Ogino // Molecular Cancer;2010, Vol. 9, p125 

    Background: Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with global DNA methylation status. LINE-1 hypomethylation in colon cancer has...

  • Colorectal cancer is reliably excluded in the frail and elderly population by minimal preparation CT. Saunders, J.; Miskovic, D.; Bowman, C.; Panto, P.; Menon, A. // Techniques in Coloproctology;Feb2014, Vol. 18 Issue 2, p137 

    Background: This study aimed to retrospectively assess the accuracy of minimal preparation computed tomography (MPCT) in the detection of colorectal cancer (CRC) within the frail and elderly population and to evaluate the relevance of extra-colonic findings (ECF). Methods: Radiology reports,...

  • Colorectal polyps: when should we tattoo? Zafar, Ali; Mustafa, Mohammed; Chapman, Mark // Surgical Endoscopy;Nov2012, Vol. 26 Issue 11, p3264 

    Background: Current guidelines recommend tattooing of suspicious-looking lesions at colonoscopy without a reference to the size of the polyp. However, the endoscopist has to make a judgement as to which lesion may be malignant and require future localisation based on the appearance and size of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics