Disfuncția endotelială, lipodistrofia şi sindromul metabolic la pacienți infectați cu HIV

September 2010
Romanian Journal of Medical Practice;2010, Vol. 5 Issue 3, p185
Academic Journal
HIV infection has become in our days a chronic disease due to the efficiency of antiretroviral (ARV) treatment. Soon after the introduction of this treatment its complications related to metabolic disturbances have been observed and studied. Metabolic syndrome was particularly described in relation with the administration of protease inhibitors (PI), as well as lipohypertrophy, an entity described in the context of the lipodystrophic syndrome. It is known that disturbances of lipid metabolism precede and accompany usually endothelial dysfunction. Also, different studies showed an association of metabolic syndrome in patients with lipodystrophy. Though, these manifestations are strongly correlated and seem to be implicated in the increased cardiovascularv risck observed in these patients. Our paper presents a synthesis of some recent data on lipodystrophy, metabolic syndrome and their relation to endothelial dysfunction in HIV infected patients.


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