TITLE

In Vivo Biological Response to Vitamin E and Vitamin-E-Doped Polyethylene

AUTHOR(S)
Jarrett, Bryan T.; Cofske, Jennifer; Rosenberg, Andrew E.; Oral, Ebru; Muratoglu, Orhun; Malchau, Henrik
PUB. DATE
November 2010
SOURCE
Journal of Bone & Joint Surgery, American Volume;11/17/2010, Vol. 92-A Issue 16, p2672
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Cross-linking has decreased the wear of ultra-high molecular weight polyethylene, a cause of osteolysis leading to total joint replacement failure. Compared with melting or annealing, doping cross-linked ultra-high molecular weight polyethylene with vitamin E stabilizes free radicals from irradiation while maintaining mechanical properties and wear resistance. This study was done to determine the local tissue effects of free vitamin E and vitamin E eluted from ultrahigh molecular weight polyethylene implants in the joint space. Methods: Three studies were performed. First, pure vitamin E and solubilized vitamin E were injected into rabbit knees to simulate vitamin-Eelution from radiation cross-linked ultra-high molecular weight polyethylene; second, vitamin-E-doped, irradiated ultra-high molecular weight polyethylene plugs were implanted into dorsal subcutaneous pouches of rabbits to detemiine the local effects of vitamin-E elution from radiation cross-linked ultra-high molecular weight polyethylene; and, third, two groups of vitamin-E-doped, irradiated acetabular liners (high surface and uniform vitamin-E concentration profiles) were compared with undoped, control ultra-high molecular weight polyethylene liners in a canine model of total hip replacement to determine the effect of possible vitamin-E elution on bone ingrowth and the local tissue response to it in a load-bearing environment. Results: Injection of solubilized vitamin E resulted in histologically normal surrounding soft tissue at both two and twelveweek follow-up intervals, while injection of pure vitamin E resulted in acute and chronic inflammation at the time of the twoweek follow-up. Both control and vitamin-E-doped subcutaneous plugs showed inflammation associated with surgery at two weeks of follow-up, but showed stable fibrous encapsulation without inflammation at twelve weeks of follow-up. In the canine total hip replacement model, there was no qualitative difference in local tissue appearance and no significant difference in the percent bone ingrowth and the percent bone density between the control and vitamin-E groups. Conclusions: These investigations showed that vitami n-E-doped ultra-high molecular weight polyethylene plugs and total hip replacement components are well tolerated in both a small and a large-animal model with no observed adverse effects on the surrounding tissues at twelve weeks of follow-up.
ACCESSION #
55513452

 

Related Articles

  • The Anti-calcification Effect of Dithiobispropionimidate, Carbodiimide and Ultraviolet Irradiation Cross-linking Compared to Glutaraldehyde in Rabbit Implantation Models. Samina Park; Soo Hwan Kim; Hong-Gook Lim; Cheong Lim; Yong Jin Kim // Korean Journal of Thoracic & Cardiovascular Surgery;2013, Vol. 46 Issue 1, p1 

    Background: Glutaraldehyde (GA) is a widely used cross-linking agent for improving mechanical properties and resistance to enzymatic degradation of collagenous tissue, but it has several drawbacks such as calcification and cytotoxicity. The aim of this study was to find the alternative effective...

  • History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene. Kurtz, Steven; Gawel, Heather; Patel, Jasmine // Clinical Orthopaedics & Related Research;Aug2011, Vol. 469 Issue 8, p2262 

    Background: Highly crosslinked polyethylene (HXLPE) was introduced to reduce wear and osteolysis in total joint arthroplasty. While many studies report wear and osteolysis associated with HXLPE, analytical techniques, clinical study design and followup, HXLPE formulation and implant design...

  • Vitamin E diffused, highly crosslinked UHMWPE: a review. Oral, Ebru; Muratoglu, Orhun K. // International Orthopaedics;Feb2011, Vol. 35 Issue 2, p215 

    Highly crosslinked UHMWPE has become the bearing surface of choice in total hip arthroplasty. First generation crosslinked UHMWPEs, clinically introduced in the 1990s, show significant improvements compared to gamma sterilised, conventional UHMWPE in decreasing wear and osteolysis. These...

  • Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review. Bracco, Pierangiola; Oral, Ebru // Clinical Orthopaedics & Related Research;Aug2011, Vol. 469 Issue 8, p2286 

    Background: Osteolysis due to wear of UHMWPE limits the longevity of joint arthroplasty. Oxidative degradation of UHMWPE gamma-sterilized in air increases its wear while decreasing mechanical strength. Vitamin E stabilization of UHMWPE was proposed to improve oxidation resistance while...

  • New water--soluble vitamin E--inhibits atherosclerosis.  // Life Extension;Sep2002, Vol. 8 Issue 9, p76 

    Discusses the abstract of a study evaluating the a water soluble form of vitamin E in inhibiting the development of atherosclerosis in hyperlipidemic rabbits. Reduction of the blood concentration of thiobarbituric acid-reactive substances; Prevention of the oxidation of low-density lipoproteins.

  • The Influence of Plastic Deformation Performed before and after Electron Beam Irradiation on the Morphology and Structural Properties of UHMWPE. MASZYBROCKA, Joanna; BARYLSKI, Adrian; CYBO, Jerzy // Solid State Phenomena;2014, Vol. 220-221, p627 

    The paper presents changes in UHMWPE morphology and structure caused by irradiation with an electron beam and plastic deformation. The input material consisted of two grades of polyethylene, i.e. GUR 1050 and GUR 1020 (Poly Hi Solidur Medi TECH), used for producing the bearing components of...

  • A Comparison of the Efficacy of Various Antioxidants on the Oxidative Stability of Irradiated Polyethylene. Hope, Natalie; Bellare, Anuj // Clinical Orthopaedics & Related Research;Mar2015, Vol. 473 Issue 3, p936 

    Background: Ultrahigh-molecular-weight polyethylene (UHMWPE) is subjected to radiation crosslinking to form highly crosslinked polyethylene (HXLPE), which has improved wear resistance. First-generation HXLPE was subjected to thermal treatment to reduce or quench free radicals that can induce...

  • Study of cross-linking process in grafted polyethylene and ethylene based copolymer using a phase resolved photoacoustic method. Dias, D. T.; Medina, A. N.; Baesso, M. L.; Bento, A. C.; Porto, M. F.; Muniz, E. C.; Rubira, A. F. // Review of Scientific Instruments;Jan2003, Vol. 74 Issue 1, p325 

    In this work, the phase resolved photoacoustic method has been employed to monitor water saturated vapor cross linking in both copolymer and grafted polyethylene. The overtone bands and stretching frequencies combinations of the -Si-OH, = CH[SUB2], -CH[SUB3], and -CH[SUB2] -CH[SUB3] were...

  • The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion. Yuan Liang; Yu Sun; Xiaolei Li; Lianqi Yan; Jingcheng Wang; Jinlong Hu; Huan Yu; Haixiang Xiao; Hui Chen; Zhongwei Sun; Jun Cai; Xinmin Feng; Chuanzhi Xiong; Jinshan He // Scientific Reports;4/11/2014, p1 

    10-Hydroxycamptothecin could reduce intraarticular adhesion by inhibiting fibroblasts proliferation after knee surgery. However, the ideal concentration of hydroxycamptothecin have not been defined. This study was tried to verify the optimal concentration of 10-hydroxycamptothecin in preventing...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics