TITLE

CORRELATION BETWEEN CARDIOVASCULAR AUTONOMIC NEUROPATHY AND DISTAL SYMMETRIC POLYNEUROPATHY IN TYPE 2 DIABETES

AUTHOR(S)
Comanescu, Alexandra Diana
PUB. DATE
May 2010
SOURCE
Romanian Journal of Neurology;May2010, Vol. 9 Issue 2, p74
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To study whether HR variability might be impaired before the clinician becomes aware for the presence of PNP and to defi ne the correlation between CAN and PNP in type 2 diabetes. Patients and method: 212 type 2 diabetic patients were examined by 5 autonomic refl ex tests: 1.deep breathing test 2.Valsalva test; 3.heart rate response during stand test; 4.orthostatic blood pressure response; 5. dyastolic blood pressure response during isometric exercise. PNP was diagnosed Michigan screening test. Results: More than half the patients without evidence of PNP were diagnosed as subclinical CAN and almost 3/4 of patients with evidence of PNP had autonomic impairment. We found a good correlation between CAN and PNP (p=0.0017). Conclusion: 1. CAN may develop fi rst and independent from PNP in type 2 diabetes. 2. Evidence of one type of neuropathy increases the risk for the other type of neuropathy. 3. Periodical survey of neurological involvement should include autonomic function testing besides the well known practice of screening for somatic neuropathy in diabetes.
ACCESSION #
55436049

 

Related Articles

  • Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood Pressure. Hoffmann, Barbara; Luttmann-Gibson, Heike; Cohen, Allison; Zanobetti, Antonella; Souza, Celine de; Foley, Christopher; Suh, Helen H.; Coull, Brent A.; Schwartz, Joel; Mittleman, Murray; Stone, Peter; Horton, Edward; Gold, Diane R. // Environmental Health Perspectives;Feb2012, Vol. 120 Issue 2, p241 

    BACKGROUND: Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes. OBJECTIVE: We examined whether short-term exposures to air pollution (fine particles, ozone) and heat resulted in...

  • Short term heart rate variability for early assessment of autonomic neuropathy in patients with type 2 diabetes mellitus: A comparative cross-sectional study. Anupama Deepak; Aithal, Kiran; Khode, Vitthal H.; Nallulwar, Shobha C. // Annals of Nigerian Medicine;Jan-Jun2014, Vol. 8 Issue 1, p4 

    Background: Cardiovascular autonomic diabetic neuropathy (CADN) is an important diabetes-associated complication. Reduced heart rate variation is the earliest indicator of CADN. Aims: The aim was to study the prospect of using short term heart rate variability (HRV) analysis for early diagnosis...

  • Association of serum adipocytokine levels with cardiac autonomic neuropathy in type 2 diabetic patients.  // Cardiovascular Diabetology;2012, Vol. 11 Issue 1, p24 

    The article presents information on a study conducted on the link between serum adipocytokines and the increased risk of cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). In the study, 142 T2DM patients participated, and their CAN was assessed and heart rate...

  • Heart Rate Variability (hrv) in Type-2-Diabetics with Improved Glycaemia Under Pioglitazone Therapy - Results of the Etapp Study. Schoenauer, Martin F.; Schoenauer, Ulrike; Luppa, Christof; Hirmer, Axel; Thomas, Andreas; Niebauer, Josef // Diabetes;Jun2007 Supplement 1, Vol. 56, pA209 

    The article focuses on the findings of a study that aims to provide an early stratification of the cardiovascular risk of insulin type-2 diabetics. It mentions that power spectral analysis was used to evaluate the heart rate variability of patients. It notes that 70 percent of the patients have...

  • Cardiovascular Autonomic Dysfunction Predicts Severe Hypoglycemia in Patients With Type 2 Diabetes: A 10-Year Follow-up Study. Jae-Seung Yun; Ji-Hyun Kim; Ki-Ho Song; Yu-Bae Ahn; Kun-Ho Yoon; Ki-Dong Yoo; Yong-Moon Park; Seung-Hyun Ko // Diabetes Care;Jan2014, Vol. 37 Issue 1, p235 

    OBJECTIVE The aim of this study was to investigate the development of severe hypoglycemia (SH) in the presence of cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS From January 2001 to December 2002, a total of 894 patients with type 2...

  • Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial. Kaminski, Diogo; Schaan, Beatriz; Silva, Antônio; Soares, Pedro; Lago, Pedro // Clinical Autonomic Research;Aug2015, Vol. 25 Issue 4, p263 

    Aims and methods: We evaluated the effects of an 8-week inspiratory muscle training (IMT, n = 5) or placebo IMT (P-IMT, n = 5) on maximal respiratory pressures, pulmonary function, functional capacity, and cardiac autonomic control in patients with type 2 diabetes and diabetic autonomic...

  • Treatment of Symptomatic Polyneuropathy With Actovegin in Type 2 Diabetic Patients. Ziegler, Dan; Movsesyan, Lusine; Mankovsky, Boris; Gurieva, Irina; Abylaiuly, Zhangentkhan; Strokov, Igor // Diabetes Care;Aug2009, Vol. 32 Issue 8, p1479 

    OBJECTIVE-- To evaluate the efficacy and safety of actovegin in patients with diabetic polyneuropathy. RESEARCH DESIGN AND METHODS-- In this multicenter, randomized, double-blind trial, 567 patients with type 2 diabetes received 20 intravenous infusions of actovegin (2,000 mg/day) (n = 281) or...

  • Natural History of Peripheral Neuropathy in Patients with Non-Insulin-Dependent Diabetes Mellitus. Partanen, Juhani; Niskanen, Leo; Lehtinen, Juha; Mervaala, Esa; Siitonen, Onni; Uusitupa, Matti // New England Journal of Medicine;7/13/95, Vol. 333 Issue 2, p89 

    Background: There is little information on the incidence and natural history of neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). Methods: We studied patients with newly diagnosed NIDDM and control subjects both at base line and 5 and 10 years later. Polyneuropathy was...

  • Increased pulse pressure a precursor to diabetes.  // Pulse;5/12/2010, Vol. 70 Issue 16, p11 

    The article provides information on a Japanese study, which found that an increase in pulse pressure in patients was related to the development of type 2 diabetes.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics