Assessing the effect of traditional Chinese medicine on CD4+ lymphocyte count of 807 HIV/AIDS cases

Jian Wang; Wen Zou; Ying Liu; Liran Xu; Fang Lu; Yuguang Wang; Guoliang Zhang; Jiaming Lu; Jun Zhou
September 2010
Journal of Biomedical Science & Engineering;Sep2010, Vol. 3 Issue 9, p833
Academic Journal
National Free Traditional Chinese Medicine (TCM) HIV/AIDS Treatment Program had been carried out for more than 5 years, treating 9267 cases accumulately by 2009. We report the 3-year outcome on CD4+ lymphocyte count of 807 cases of HIV/AIDS enrolled in the National Free TCM HIV/AIDS Treatment Program, the CD4+ lymphocyte count were measured every 6 month at 7 time points (0, 6, 12, 18, 24, 30, 36 month). The results showed that the overall CD4+ ly mphocyte count maintained stable at the 6th month and the 12th month, declined significantly at the 18th month, 24th month and 30th month, then elevated to the pre-treatment level at the 36th month. Patients with pre-treatment CD4+ lymphocyte count level < 200/mm3, who possibly combined HAART therapy, had CD4+ lymphocyte count elevated significantly after all visits. Patients with pre-treatment CD4+ lymphocyte count level between 200 and 350/mm3 maintained stable before the 36th month, and then rosed significantly, which implicated the long-term effect of TCM. Patients with pre-treatment CD4+ lymphocyte count level > 350/mm3 had CD4+ lymphocyte count declined significantly after all visits. In summary, combined treatment of Chinese herbal medicine and conventional therapy on HIV/AIDS suggested promising effect, but more evidences from larger, rigorous designed studies still needed to support the affirmative effect of TCM in the future.


Related Articles

  • Treatment of acquired immunodeficiency syndrome with chinese medicine in China: Opportunity, advancement and challenges. Liu, Zhi-bin; Wang, Xin; Liu, Hui-juan; Jin, Yan-tao; Guo, Hui-jun; Jiang, Zi-qiang; Li, Zhen; Xu, Li-ran // Chinese Journal of Integrative Medicine;Aug2013, Vol. 19 Issue 8, p563 

    Chinese medicine (CM) has been used in the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) for 30 years and the demonstrated therapeutic effects of CM, such as reducing plasma HIV viral load, increasing CD4T cell counts, promoting immunity...

  • Use of Highly Active Antiretroviral Therapy in a Cohort of HIV-Seropositive Women. Cook, Judith A.; Cohen, Mardge H.; Grey, Dennis; Kirstein, Lynn; Burke, Jane; Anastos, Kathryn; Palacio, Herminia; Richardson, Jean; Wilson, Tracey E.; Young, Mary // American Journal of Public Health;Jan2002, Vol. 92 Issue 1, p82 

    Objectives. This study examined longitudinal trends in use of highly active antiretroviral therapy (HAART) among a cohort of HIV-positive participants in the Women's Interagency HIV Study. Methods. Beginning in 1994, 1690 HIV-positive women reported detailed information about their use of...

  • A Social-Ecological View of Barriers and Facilitators for HIV Treatment Adherence: Interviews with Puerto Rican HIV Patients. Castro, Eida M.; Santiago, Lydia E.; Jiménez, Julio C.; Dávila-Vargas, Daira; Rosal, Milagros C. // PLoS ONE;09/30/2015, Vol. 10 Issue 10, p1 

    Purpose: To identify perceived barriers and facilitators for HAART adherence among people living with HIV/AIDS in Southern Puerto Rico using a Social Ecological framework. Patients and Methods: Individual in-depths interviews were conducted with 12 HIV patients with a history of HAART...

  • Integrase inhibitors in the treatment of HIV-1 infection. Powderly, William G. // Journal of Antimicrobial Chemotherapy (JAC);Dec2010, Vol. 65 Issue 12, p2485 

    Agents active against HIV type 1 (HIV-1) that target the viral integrase by inhibiting the strand transfer step of integration have now entered the clinical arena. Raltegravir is the first in this new class. Clinical trials in treatment-experienced and in treatment-naive patients have shown that...

  • Prevalence of Hypertension in HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART) Compared with HAART-Naïve Patients at the Limbe Regional Hospital, Cameroon. Dimala, Christian Akem; Atashili, Julius; Mbuagbaw, Josephine C.; Wilfred, Akam; Monekosso, Gottlieb L. // PLoS ONE;2/10/2016, Vol. 11 Issue 2, p1 

    Background: Highly active antiretroviral therapy (HAART) has greatly reduced the morbidity and mortality of HIV/AIDS patients but has also been associated with increased metabolic complications and cardiovascular diseases. Data on the association between HAART and hypertension (HTN) in Africa...

  • Immune Activation While on Potent Antiretroviral Therapy Can Predict Subsequent CD4+ T-Cell Increases Through 15 Years of Treatment. Xinyan Zhang; Hunt, Peter W.; Hammer, Scott M.; Cespedes, Michelle S.; Patterson, Kristine B.; Bosch, Ronald J. // HIV Clinical Trials (Thomas Land Publishers Incorporated);Mar/Apr2013, Vol. 14 Issue 2, p61 

    Background: While persistent T-cell activation has been cross-sectionally associated with poor CD4+ T-cell restoration in HIV-infected individuals maintaining antiretroviral treatment (ART)-mediated viral suppression, it remains unclear whether CD8+ T-cell activation is of predictive effect on...

  • Costing of scaling up HIV/AIDS treatment in Mexico. Bautista-Arredondo, Sergio; Dmytraczenko, Tania; Kombe, Gilbert; Bertozzi, Stefano M. // Salud Pública de México;nov2008 Supplement, Vol. 50, pS437 

    Objective. To determine the net effect of introducing highly active antiretroviral treatment (HAART) in Mexico on total annual per-patient costs for HIV/AIDS care, taking into account potential savings from treatment of opportunistic infections and hospitalizations. Material and Methods. A...

  • Safety and Efficacy of Setarud (IMOD) Among People Living with HIV/AIDS: A Review. Paydary, Koosha; Emamzadeh-Fard, Sahra; Khorshid, Hamid Reza Khorram; Kamali, Koorosh; Alinaghi, SeyedAhmad Seyed; Mohraz, Minoo // Recent Patents on Anti-Infective Drug Discovery;Apr2012, Vol. 7 Issue 1, p66 

    The broad use of highly active anti-retroviral therapy (HAART), especially in developing world, has been associated with several problems such as lactic acidosis, lipodistrophy, pancreatitis, hyperlipidemia, insulin resistance and hepatotoxicity. Extensive use of HAART has also resulted in...

  • FACTORS INFLUENCING HAART ADHERENCE AMONG PRIVATE HEALTH CARE SECTOR PATIENTS IN A SUBURB OF THE ETHEKWINI METRO. Naidoo, Panjasaram // African Journal of Primary Health Care & Family Medicine;2009, Vol. 1 Issue 1, p28 

    Background: The advent of highly active antiretroviral therapy (HAART) ushered in a new era in the management of the AIDS pandemic with new drugs, new strategies, new vigour from treating clinicians and enthusiasm on the part of their patients. What soon became evident, however, was the vital...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics