Myelitis and Ascending Flaccid Paralysis Due to Congenital Toxoplasmosis

Monini, Paolo; Sirianni, Maria Caterina; Franco, Marina; Vincezi, Laura; Topino, Simone; Goletti, Delia; Leone, Patrizia; Leone, Pasqualina; Chiozzini, Chiara; Nicastri, Emmanuele; Andreoni, Massimo; Borduagni, Osvaldo; Sgadari, Cecilia; Rezza, Giovanni; Sturzl, Michael; Ensoli, Barbara
November 2001
Clinical Infectious Diseases;11/15/2001, Vol. 33 Issue 10, p1778
Academic Journal
A 4-week-old female newborn developed ascending flaccid paralysis and radiologic evidence of myelitis; the diagnosis of congenital toxoplasmosis was confirmed by the presence of Toxoplasma gondii-specific immunoglobulins in both mother and infant, and detection of Toxoplasma sequences in the infant's cerebrospinal fluid by polymerase chain reaction analysis. Treatment with pyrimethamine, sulfadiazine, and methylprednisolone resulted in improvement.


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