Subcutaneous phaeohyphomycosis due to Exophiala spinifera in an immunocompromised host

Radhakrishnan, Deepa; Jayalakshmi, G.; Madhumathy, A.; Banu, S. Thasneem; Geethalakshmi, S.; Sumathi, G.
October 2010
Indian Journal of Medical Microbiology;Oct2010, Vol. 28 Issue 4, p396
Academic Journal
A case of phaeohyphomycosis presenting as multiple subcutaneous abscesses in a young lady with deteriorating liver function was reported here. The lesion started as a solitary abscess in the neck, mimicking tuberculous cold abscess and rapidly involved the face, chest, arms, and legs within six months with ulceration and discharge of thick brownish foul smelling pus. Potassium hydroxide mount of pus from various sites revealed septate dematiaceous hyphae and pseudohyphae. Culture yielded pure growth of Exophiala spinifera. Tissue debridement was done along with initiation of antifungal therapy with ketoconazole. As liver function deteriorated, antifungal therapy was withdrawn after seven days. Patient expired three weeks after admission due to hepatic failure.


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