TITLE

Prevalence of hepatitis C virus genotypes and impact of T helper cytokines in achieving sustained virological response during combination therapy: A study from Central India

AUTHOR(S)
Mishra, P. K.; Bhargava, A.; Khan, S.; Pathak, N.; Punde, R. P.; Varshney, S.
PUB. DATE
October 2010
SOURCE
Indian Journal of Medical Microbiology;Oct2010, Vol. 28 Issue 4, p358
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Characterisation of host immune response to hepatitis C virus (HCV) genotypes may have an important prognostic and therapeutic implication. Genotype-3 was more prevalent in the examined cohort and demonstrated a significantly higher response to combination therapy than genotype-1. Sustained virological response (SVR) was 94.74% in genotype-3 and 45.45% in genotype-1. The patients who achieved SVR reported higher levels of circulating T helper 1 cytokines in comparison to subjects with no SVR in both the studied groups. Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients.
ACCESSION #
55249696

 

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