Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model

Alkharfy, Khalid M.
January 2009
Experimental Diabetes Research;2009, Special section p1
Academic Journal
Background/Aims. Diabetic patients usually require more medications than their nondiabetic counterparts. This work examined the effect of hyperglycemia on the pharmacokinetic properties of cyclosporine in a diabetic dog model. Main Methods. Diabetes was induced using a streptozotocin/alloxan combination and verified by measuring the serum glucose level. Cyclosporine was administered as a bolus intravenous dose of 5 mg/kg, and blood samples were collected at different time points for determining drug concentrations and biochemical analyses. Results. Diabetic dogs showed a significant increase in total body clearance of cyclosporine compared to healthy controls (0.457 L hr-1 Kg-1 versus 0.201 L hr-1 Kg-1, P = .0019) and a decrease in its biological half-life (9.32 hours versus 22.56 hours, P = .0125). In addition, diabetic animals exhibited a higher total cholesterol (7.20 ± 0.62 mmol/L and 5.28 ± 0.36 mmol/L; P < .05) as well as more serum low density lipoproteins (4.45 ± 0.72 mmol/L versus 1.06 ± 0.10 mmol/L; P < .05). Conclusion. Overt diabetes alters cyclosporine disposition by modulating its clearance. Abnormalities in the lipid profile, among other factors, may contribute to the accelerated metabolic degradation of cyclosporine under hyperglycemic conditions.


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