Substituting placebo for established, effective therapy: Why not?

Shapiro, Stan; Fergusson, Dean; Cranley Glass, Kathleen
November 2010
CMAJ: Canadian Medical Association Journal;11/9/2010, Vol. 182 Issue 16, p1749
Academic Journal
The article offers the authors' insights on substituting placebo for established, effective therapy. They tackle the practical implications of assay sensitivity and explore the reasons why some still endorse and strongly advocate for placebo controls despite its ethical concerns. They believe that placebo controls have an important role in randomized controlled trials but stress the significance of examining the decisions about their use.


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