TITLE

Microcomputed Tomography Characterization of Shoulder Osseous Deformity After Brachial Plexus Birth Palsy: A Rat Model Study

AUTHOR(S)
Zhongyu Li; Barnwell, Jonathan; Tan, Josh; Koman, L. Andrew; Smith, Beth P.
PUB. DATE
November 2010
SOURCE
Journal of Bone & Joint Surgery, American Volume;11/3/2010, Vol. 92-A Issue 15, p2583
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Shoulder deformities are common secondary sequelae associated with brachial plexus birth palsy. The aim of the present study was to characterize three-dimensional glenohumeral deformity associated with brachial plexus birth palsy with use of microcomputed tomography scanning in a recently developed animal model. Methods: Brachial plexus birth palsy was produced by a right-sided neurotomy of the C5 and C6 nerve roots in seven five- day-old Sprague-Dawley rats. Microcomputed tomography scanning was performed when the rats were four months of age. Glenoid size, version, and inclination; humeral head size; and acromion-glenoid distance were measured. Normal shoulders of age-matched rats (n = 9) served as controls. Statistical analysis was performed with use of the unpaired two-tailed Student t test. Results: There were significant increases in glenoid retroversion (-7.6° ± 4~90 compared with 3.6° ± 2.1°; p = 0.038) and glenoid inclination (38.7° ± 7°3° compared with 11.2° ± 1.9°; p = 0.015) in the shoulders with simulated brachial plexus birth palsy in comparison with the normal, control shoulders. The glenohumeral joints were more medialized in the joints with simulated brachial plexus birth palsy as reflected by the acromion-glenoid distance measurement; however, the difference was not significant (3.20 ± 0.51 compared with 2.40 ± 0.18 mm; p = 0.12). Although the mean humeral head height and width measurements, on the average, were smaller in the brachial plexus birth palsy shoulders as compared with the normal, control shoulders, only the measurement of humeral head height was significantly different between the two groups (4.25 ± 2.02 compared with 4.97 ± 0.11mm [p = 0.0081 and 3.56 ± 0.27 compared with 4.19 ± 0.17 mm [p = 0.0561, respectively). Conclusions: In this animal model, rats with simulated brachial plexus birth palsy developed gross architectural joint distortion characterized by increased glenoid retroversion and inclination. In addition, humeral heads tended to be smaller four months after simulated brachial plexus birth palsy. Clinical Relevance: Combined with the microcomputed tomography technique, this animal model may provide a useful means of studying the natural history of shoulder deformity associated with brachial plexus birth palsy.
ACCESSION #
55152032

 

Related Articles

  • Shoulder arthrodesis with a reconstruction plate. Chun, Jae; Byeon, Hwa // International Orthopaedics;Aug2009, Vol. 33 Issue 4, p1025 

    From 1995 to 2005, arthrodesis with a reconstruction plate was performed for eight shoulders. The average follow-up period was 44 months. The indications for shoulder arthrodesis were joint destruction as a sequel of tuberculous arthritis, malignant bone tumour, pyogenic arthritis, failed...

  • Shoulder function and anatomy in complete obstetric brachial plexus palsy: long-term improvement after triangle tilt surgery. Nath, Rahul K.; Karicherla, Priyanka; Mahmooduddin, Faiz // Child's Nervous System;Aug2010, Vol. 26 Issue 8, p1009 

    Untreated complete obstetric brachial plexus injury (COBPI) usually results in limited spontaneous recovery of shoulder function. Older methods used to treat COBPI have had questionable success, with very few studies being published. The purpose of the current study was to examine the results of...

  • Glenohumeral Deformity in Children with Brachial Plexus Birth Injuries.  // Bulletin of the NYU Hospital for Joint Diseases;2011, Vol. 69 Issue 1, p36 

    No abstract available.

  • The Early Effects of Tendon Transfers and Open Capsulorrhaphy on Glenohumeral Deformity in Brachial Plexus Birth Palsy. Waters, Peter M.; Bae, Donald S. // Journal of Bone & Joint Surgery, American Volume;Oct2009 Supplement 2, Vol. 91-A Issue 2, p213 

    BACKGROUND: Persistent muscle imbalance and soft-tissue contractures can lead to progressive glenohumeral joint dysplasia in patients with brachial plexus birth palsy. The objective of the present investigation was to determine the effects of tendon transfers and open glenohumeral reduction on...

  • Micro-CT evaluation of spontaneous cure rate of rat alveolar bone defect man-made. XU Yue; CHEN Zhen-qi; WU Jun; LI Ren-mei; LIU Guang-peng // China Journal of Oral & Maxillofacial Surgery;Mar2011, Vol. 9 Issue 2, p126 

    PURPOSE: To evaluate the spontaneous cure rate of the SD rat's alveolar bone defects with two different sizes using micro-CT. METHODS: 18 SD rats (7 weeks old) were selected, and divided into group A and B. A 3mmx3mmx2mm and a 4mmx4 mmx3mm complete alveolar defect were created in Group A and...

  • Evaluation of four pyridine analogs to characterize 6-OHDA-induced modulation of mGluR5 function in rat brain using microPET studies. Aijun Zhu; Xukui Wang; Meixiang Yu; Ji-Quan Wang; Brownell, Anna-Liisa // Journal of Cerebral Blood Flow & Metabolism;Sep2007, Vol. 27 Issue 9, p1623 

    Micro-positron emission tomography imaging studies were conducted to characterize modulation of metabotropic glutamate subtype-5 receptor (mGluR5) function in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease using four analogical PET ligands:...

  • In vivo imaging of neuroinflammation: a comparative study between [18F]PBR111, [11C]CLINME and [11C]PK11195 in an acute rodent model. van Camp, Nadja; Boisgard, Raphael; Kuhnast, Bertrand; Thézé, Benoit; Viel, Thomas; Grégoire, Marie-Claude; Chauveau, Fabien; Boutin, Hervé; Katsifis, Andrew; Dollé, Frédéric; Tavitian, Bertrand // European Journal of Nuclear Medicine & Molecular Imaging;May2010, Vol. 37 Issue 5, p962 

    The key role of neuroinflammation in acute and chronic neurological disorders has stimulated the search for specific radiotracers targeting the peripheral benzodiazepine receptor (PBR)/18 kDa translocator protein (TSPO), a hallmark of neuroinflammation. Here we evaluate the new radiotracer for...

  • Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. Müller, Robert; Kampschulte, Marian; Khassawna, Thaqif; Schlewitz, Gudrun; Hürter, Britta; Böcker, Wolfgang; Bobeth, Manfred; Langheinrich, Alexander; Heiss, Christian; Deutsch, Andreas; Cuniberti, Gianaurelio // Medical & Biological Engineering & Computing;Apr2014, Vol. 52 Issue 4, p405 

    For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague-Dawley rats were (1) euthanized...

  • Cross-validation of Input Functions Obtained by HO PET Imaging of Rat Heart and a Blood Flow-through Detector. Kudomi, Nobuyuki; Sipilä, Hannu; Autio, Anu; Oikonen, Vesa; Liljenbäck, Heidi; Tarkia, Miikka; Laivola, Jarno; Johansson, Jarkko; Teräs, Mika; Roivainen, Anne // Molecular Imaging & Biology;Aug2012, Vol. 14 Issue 4, p509 

    Purpose: Positron emission tomography (PET) with O-labeled water (HO) facilitates the visualization and quantification of blood flow in clinical investigations and also in small animals. The quantification of blood flow requires an input function, which is generally obtained by measuring...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics