Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii

Chopra, Sidharth; Torres-Ortiz, Maria; Hokama, Leslie; Madrid, Peter; Tanga, Mary; Mortelmans, Kristien; Kodukula, Krishna; Galande, Amit K.
December 2010
Journal of Antimicrobial Chemotherapy (JAC);Dec2010, Vol. 65 Issue 12, p2598
Academic Journal
Objective The rising occurrence of drug-resistant pathogens accentuates the need to identify novel antibiotics. We wanted to identify new scaffolds for drug discovery by repurposing FDA-approved drugs against Acinetobacter baumannii, an emerging Gram-negative nosocomial drug-resistant pathogen. Materials and methods In this study, we screened 1040 FDA-approved drugs against drug-susceptible A. baumannii ATCC 17978 and drug-resistant A. baumannii BAA-1605. Results and discussion Twenty compounds exhibited significant antimicrobial activity (MIC ≤8 mg/L) against ATCC 17978 while only five compounds showed such activity against BAA-1605. Among the most notable results, tyrothricin, a bactericidal antibiotic typically active only against Gram-positive bacteria, exhibited equipotent activity against both strains. Conclusion The paucity of identified compounds active against drug-resistant A. baumannii exemplifies its ability to resist antimicrobials as well as the resilience of drug-resistant Gram-negative pathogens. Repurposing of approved drugs is a viable alternative to de novo drug discovery and development.


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