TITLE

Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats

AUTHOR(S)
Funakami, Yoshinori; Itoh, Eiji; Hata, Taeko; Wada, Tetsuyuki; Ichida, Seiji
PUB. DATE
January 2010
SOURCE
BioPsychoSocial Medicine;2010, Vol. 4, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin a1-receptor agonist phenylephrine on stress-induced OH in SART-stressed rats and unstressed rats. Methods: Male Wistar rats weighing 250-300 g were used. Rats were fixed in the supine position under urethane anesthesia. Blood pressure was directly measured from the left common carotid artery and ECG was recorded simultaneously. Results: The maximum decrease in blood pressure and the area under the blood pressure-time curve were both large, while the %reflex was small in the SART-stressed rats compared with unstressed rats. In the SART-stressed rats, prolonged intravenous administration of phenylephrine reduced OH at a dose that barely affected unstressed rats. Conclusion: The results suggested that sympathetic dysfunction is a factor underlying SART stress-induced OH.
ACCESSION #
55099845

 

Related Articles

  • Sympathetic Responses to Valsalva's Manoeuvre Following Bed Rest. Shoemaker, J. Kevin; Hogeman, Cynthia S.; Sinoway, Lawrence I. // Canadian Journal of Applied Physiology;Jun2003, Vol. 28 Issue 3, p342 

    The purpose of this study was to examine whether 14 days of head-down tilt bed rest (HDBR) alters autonomic regulation during Valsalva's manoeuvre (VM) and if this would predict blood pressure control during a 60° head-up tilt (HUT) test. To examine autonomic control of blood pressure, we...

  • Acute Effect Of Spinal Anesthesia On Intraocular Pressure. ŞEKERYAPAN, Berrak; BOSTAN, Habib; TOMAK, Yakup; TÜRKYILMAZ, Kemal; ÖNER, Veysi; DURMUŞ, Mustafa // Glokom-Katarakt/Journal of Glaucoma-Cataract;Sep2013, Vol. 8 Issue 3, p185 

    Purpose: The aim of this study was to evaluate the acute effect of spinal anesthesia on intraocular pressure (IOP) in supine positioned patients underwent lower extremity surgery. Materials and Methods: IOP was measured in all patients with Tono-Pen XL before and 20 minutes after spinal...

  • The Support of the Venous Circulation. Beninson, Joseph; Jobst, Caroline B. // Angiology;Jul1982, Vol. 33 Issue 7, p442 

    The article presents information on the support of the Venous circulation. When life forms left and primeval seas to live on dry land they lost the hydrostatic support afforded their venous circulation and set the stage for venous insufficiency in all of its manifestations. When the first...

  • Noninvasive assessment of arterial distensibility in adolescents using the second derivative of photoplethysmogram waveform. Miyai, Nobuyuki; Miyashita, Kazuhisa; Arita, Mikio; Morioka, Ikuharu; Kamiya, Kazuyo; Takeda, Shintaro // European Journal of Applied Physiology;Dec2001, Vol. 86 Issue 2, p119 

    To clarify the clinical usefulness of the second derivative of the waveform of the fingertip photoplethysmogram (SDPTG), we examined the relationship between the pattern of the SDPTG waveform and risk factors related to atherosclerosis in 1,495 boys and girls aged 9–17 years. The...

  • Influence of Blood Pressure Manometer Feedback on the Parameters of the Vestibular Evoked Myogenic Potential Test. Myung-Whan Suh; Ji Soo Kim; Ja-Won Koo // Annals of Otology, Rhinology & Laryngology;Apr2009, Vol. 118 Issue 4, p281 

    Objectives: The objective of this study was to evaluate the merits of a blood pressure (BP) manometry feedback method for measurement of vestibular evoked myogenic potentials. Methods: Sixty ears of 30 normal volunteers were prospectively investigated. The vestibular evoked myogenic potentials...

  • Post-Weaning Protein Malnutrition Increases Blood Pressure and Induces Endothelial Dysfunctions in Rats. Belchior, Aucelia C. S. de; Angeli, Jhuli K.; Faria, Thaís de O.; Siman, Fabiana D.M.; Silveira, Edna A.; Meira, Eduardo F.; Costa, Carlos P. da; Vassallo, Dalton V.; Padilha, Alessandra S. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Malnutrition during critical periods in early life may increase the subsequent risk of hypertension and metabolic diseases in adulthood, but the underlying mechanisms are still unclear. We aimed to evaluate the effects of post-weaning protein malnutrition on blood pressure and vascular...

  • Antihypertensive Treatment Differentially Affects Vascular Sphingolipid Biology in Spontaneously Hypertensive Rats. Spijkers, Léon J. A.; Janssen, Ben J. A.; Nelissen, Jelly; Meens, Merlijn J. P. M. T.; Wijesinghe, Dayanjan; Chalfant, Charles E.; De Mey, Jo G. R.; Alewijnse, Astrid E.; Peters, Stephan L. M. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Background: We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolated carotid arteries of SHR leads to...

  • Effects of exercise training on arterial-cardiac baroreflex function in POTS. Galbreath, M. Melyn; Shibata, Shigeki; VanGundy, Tiffany B.; Okazaki, Kazunobu; Qi Fu; Levine, Benjamin D. // Clinical Autonomic Research;Apr2011, Vol. 21 Issue 2, p73 

    Purpose: Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these...

  • 'Normal' values may signal life-threatening trauma for elderly.  // ED Nursing;Dec2007, Vol. 11 Issue 2, p13 

    Elder trauma patients are different from other age groups in many ways, and "normal" lab values and vital sign ranges might be misleading, says a new study. To avoid missing a life-threatening injury, determine baseline values for blood pressure, lactate, and base deficit levels. •...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics