TITLE

Short-term effects of transcatheter aortic valve implantation on neurohormonal activation, quality of life and 6-minute walk test in severe and symptomatic aortic stenosis

AUTHOR(S)
Gotzmann, Michael; Hehen, Tobias; Germing, Alfried; Lindstaedt, Michael; Yazar, Aydan; Laczkovics, Axel; Mumme, Achim; Mügge, Andreas; Bojara, Waldemar
PUB. DATE
July 2010
SOURCE
Heart;Jul2010, Vol. 96 Issue 14, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective This prospective study aimed to determine to what extent clinical symptoms and neurohumoral activation are improved in patients with severe aortic valve stenosis after transcatheter aortic valve implantation (TAVI) with the CoreValve prosthesis. Methods From June 2008 to June 2009 consecutive patients with symptomatic severe aortic valve stenosis (area<1 cm²), age≥75 years with a logistic EuroSCORE ≥15% or age>60 years plus additional specified risk factors were evaluated for TAVI. Examinations of study patients were performed before and 30 days after TAVI and comprised assessment of quality of life (Minnesota living with heart failure questionnaire, [MLHFQ]) 6-minute walk test, measurement of B-type natriuretic peptide and echocardiography. Aortic valve prosthesis was inserted retrograde using a femoral arterial or a subclavian artery approach. Results In 44 consecutive patients (mean age 79.1±7 years, 50% women, mean left ventricular ejection fraction 55.8±8.5%) TAVI was successfully performed. Follow-up 30 days after TAVI showed a significantly improved quality of life (baseline 44±19.1 vs 28±17.5 MLHFQ Score, p<0.001) and an enhanced distance in the 6-minute walk test (baseline 204±103 vs 266±123 m, p<0.001). B-type natriuretic peptide levels were reduced (baseline 725±837 vs 423±320 pg/ml, p=0.005). Conclusions Our preliminary results show a significant clinical benefit and a reduction of neurohormonal activation in patients with severe and symptomatic aortic valve stenosis early after TAVI.
ACCESSION #
55071798

 

Related Articles

  • TAVI Improves QoL in Patients Suitable for Transfemoral TAVI.  // MD Conference Express;Dec2011, p4 

    The article discusses how transcatheter aortic valve implantation (TAVI) improved quality of life (QoL) in patients with aortic stenosis. The PARTNER trial presented by doctor David J. Cohen has noted the overall impact of alternative treatments on QoL from the views of the patient. Results...

  • Značaj natriuretskih peptida u proceni težine aortne stenoze. Davičević, Žaklina; Tavčiovski, Dragan; Matunović, Radomir; Vukotić, Snježana; Mijailović, Zdravko // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Aug2010, Vol. 67 Issue 8, p622 

    Background/Aim. Symptom onset is a critical point in natural course of aortic stenosis and the most important indication for aortic valve replacement. The aim of the study was to evaluate the role of natriuretic peptides level in the assessment of symtomatic status of patients with severe aortic...

  • Relationship between N-terminal pro- B type natriuretic peptide and extensive echocardiographic parameters in mild to moderate aortic stenosis. Arslan, Ugur; Cemri, M.; Kocaman, S. A.; Çengel, A. // Journal of Postgraduate Medicine;Jan-Mar2008, Vol. 54 Issue 1, p12 

    Context: The N-terminal pro-B type natriuretic peptide levels (NT pro-BNP) are increased in cases of volume or pressure overload. Aims: To examine NT pro-BNP levels and enclose whether any relationship is present between the levels of NT pro-BNP and extensive echocardiographic parameters in...

  • Treadmill exercise in apparently asymptomatic patients with moderate or severe aortic stenosis: relationship between cardiac index and revealed symptoms. Rajani, Ronak; Rimington, Helen; Chambers, John B. // Heart;May2010, Vol. 96 Issue 9, p689 

    Objectives To test whether symptoms revealed on exercise testing in patients with moderate or severe aortic stenosis are associated with changes in left ventricular systolic function and to investigate the ability of resting measures to predict peak cardiac index. Methods In a prospective study...

  • A message from Dr. Kereiakes. Kereiakes, Dean J. // Cincinnati Magazine;Mar2011, Vol. 44 Issue 6, special section p2 

    An introduction to the journal is presented in which the editor discusses various reports published within the issue including one on a treatment for symptomatic aortic valve stenosis (AS) and one on the initial results of the PARTNER trial, a catheter-based procedure to non-surgically replace...

  • CLINICAL STUDIES ASSESSING TRANSCATHETER AORTIC VALVE REPLACEMENT. Raheem, Shaheena; Popma, Jeffrey J. // Methodist DeBakey Cardiovascular Journal;Jun2012, Vol. 8 Issue 2, p13 

    The article presents clinical trials which examine the value of transcatheter aortic valve replacement (TAVR) in patients fitted for surgical aortic valve replacement (sAVR). The study reveals that death rates from any cause were 3.4% in the group of TAVR and 6.5% in the group of sAVR at 30...

  • Images In Cardiology: Unicuspid aortic valve Krishnamoorthy, K M // Heart;Feb2001, Vol. 85 Issue 2, p217 

    The article offers information on a unicuspid unicommissural valve revealed through transoesophageal echocardiography in a 16-year-old boy with aortic stenosis.

  • Echocardiographic Estimation of Arotic-Valve Gradietn in Aortic Stenosis. Schwartz, Allan; Vignola, Paul A.; Walker, Harriet J.; King, Mary Etta; Goldblatt, Allan // Annals of Internal Medicine;Sep78, Vol. 89 Issue 3, p329 

    Features a study which examined the use of echocardiographic technique in assessing the severity of aortic stenosis in a consecutive group of children and adults with suspected left ventricular outflow obstruction scheduled to undergo cardiac catherization. Characteristics of aortic stenosis;...

  • Aortic balloon valvuloplasty in corrected transposition of the great arteries with severe valvular aortic stenosis of congenital bicuspid aortic valve. Patnaik, Amar N.; Barik, Ramachandra; Nemani, Lalita; Saikh, Subhani // Annals of Pediatric Cardiology;Sep-Dec2014, Vol. 7 Issue 3, p247 

    A letter to the editor is presented related to use of aortic balloon valvuloplasty in congenital corrected transposition of great arteries (CCTGA) with congenital bicuspid aortic valve's valvular aortic stenosis.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics