TITLE

Premenstrual Asthma: Epidemiology, Pathogenesis and Treatment

AUTHOR(S)
Tan, K.S.
PUB. DATE
November 2001
SOURCE
Drugs;Nov2001, Vol. 61 Issue 14, p2079
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The exacerbation of asthma in the premenstrual period has long been of interest. Premenstrual asthma has been estimated to affect up to 40% of females with asthma, although the exact prevalence of this phenomenon is unclear as studies have involved small numbers in hospital clinics. Large-scale community-based studies are required to estimate its true prevalence. Researchers are slowly piecing together clues as to the aetiology and pathogenesis of the disorder. Female sex-steroid hormones play an important role but the exact mechanism is still unknown. Recent evidence suggests that increased airway hyperresponsiveness, an indicator of underlying airway inflammation, during the luteal phase of the menstrual cycle may account for premenstrual exacerbations. In addition, there is now evidence of impaired or altered β-adrenoceptor function and regulation in females with asthma, which may have a part to play. Accurate diagnosis is dependent on a detailed history and the demonstration of premenstrual dip in peak expiratory flow. Exacerbations in the majority of women will respond to the usual treatment of bronchial asthma. However, a few women will experience significant morbidity or treatment-related adverse effects. Case reports suggest that the combined oral contraceptive pill or gonadotrophin-releasing hormone analogues may be effective in these patients. This requires substantiation by randomised controlled trials.
ACCESSION #
5500882

 

Related Articles

  • Killer PMS? Try this. J. D. A. // Prevention;Jan2006, Vol. 58 Issue 1, p42 

    The article presents information about an alternative treatment for premenstrual dysphoric disorder (PMDD), a new kind of birth control pill called Yaz. PMDD is usually treated with antidepressants or low-dose birth control pills. PMDD is caused in part by pre-period hormone fluctuations. Yaz...

  • Hormonal interventions may provide relief of some of the symptoms of premenstrual syndrome.  // Drugs & Therapy Perspectives;Jan2004, Vol. 20 Issue 1, p11 

    Premenstrual syndrome (PMS), with symptoms including anxiety, tension, irritability, depression, headache, fatigue and breast tenderness, is a condition that affects the majority of women at some stage of life. Although not fully understood, PMS may be linked to the development of the corpus...

  • Changes in functioning of mesolimbic incentive processing circuits during the premenstrual phase. Ossewaarde, Lindsey; van Wingen, Guido A.; Kooijman, Sabine C.; Bäckström, Torbjörn; Fernández, Guillén; Hermans, Erno J. // Social Cognitive & Affective Neuroscience;Oct2011, Vol. 6 Issue 5, p612 

    The premenstrual phase of the menstrual cycle is associated with marked changes in normal and abnormal motivated behaviors. Animal studies suggest that such effects may result from actions of gonadal hormones on the mesolimbic dopamine (DA) system. We therefore investigated premenstrual changes...

  • THE ANTIOESTROGEN TOREMIFENE HAS LUTEOTROPIC EFFECTS IN WOMEN SUFFERING FROM PREMENSTRUAL MASTALGIA. Oksa, Sinikka; Luukkaala, Tiina; Mäenpää, Johanna // Acta Endocrinologica (1841-0987);Oct-Dec2008, Vol. 4 Issue 4, p425 

    Background. Prior studies examining cyclic mastalgia and sex hormones have failed to reveal any specific endocrine cause and their results of them are inconsistent. Aim. To evaluate luteal hormonal levels in women with marked premenstrual mastalgia in response to toremifene. Methods. In a...

  • Duphaston.  // Royal Society of Medicine: Medicines;2002, p219 

    This article presents information on Duphastonc from Solvay. This is a proprietary, prescription-only preparation of the dydrogesterone. It can be used to treat many conditions of hormonal deficiency in women, including menstrual problems, premenstrual syndrome, endometriosis, recurrent...

  • dydrogesterone.  // Royal Society of Medicine: Medicines;2002, p220 

    This article presents information on the drug dydrogesterone, which is a progestogen, an analogue of the sex hormone used to treat conditions of hormonal deficiency in women, including menstrual problems, premenstrual syndrome, displacement of uterus-lining tissue (endometriosis), recurrent...

  • dydrogesterone. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p249 

    An encyclopedia entry for "dydrogesterone" is presented. It refers to a drug that is derived from the female sex hormone progesterone. The drug is used to treat premenstrual syndrome and certain menstrual problems. It is also given together with an oestrogen drug as hormone replacement therapy...

  • Eat Right to Ease PMS. Knittel, Linda // Yoga Journal;May/Jun2003, Issue 174, p36 

    Presents a study on the importance of vegetable, fruits, nuts and seeds to increase the sex hormone-binding globulin in the blood and to soothe premenstrual symptoms (PMS) in the U.S. Significance of magnesium and calcium in the prevention of PMS; Type of foods triggering the PMS; Enhancement...

  • Premenstrual dysphoric disorder: literature review. Fryer, C. P.; Kaspi, S. P.; Fallon, S. K.; Moline, M. L.; Severino, S. K. // Archives of Women's Mental Health;1999, Vol. 2 Issue 1, p1 

    The original research literature concerning premenstrual disorders appearing since the review of the American Psychiatric Association's DSM-IV work group in 1994 is reviewed. Principal areas covered include methodologic approaches to premenstrual dysphoric disorder and related syndromes;...

Share

Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics