TITLE

Isolation and Characterization of the Human Forkhead Gene FOXQ1

AUTHOR(S)
Bieller, Annette; Pasche, Bastian; Frank, Susanne; Gl�ser, Birgitta; Kunz, J�rgen; Witt, Kathrin; Zoll, Barbara
PUB. DATE
September 2001
SOURCE
DNA & Cell Biology;Sep2001, Vol. 20 Issue 9, p555
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have isolated a human genomic and cDNA clone that encodes a protein of 403 amino acids and belongs to the family of the FOX transcription factors (previously called HNF-3/forkhead transcription factors). The 2.7-kb transcript of the human FOXQ1 gene is expressed predominantly in the stomach, trachea, bladder and salivary gland. Additionally, overexpression of human FOXQ1 was shown in colorectal adenocarcinoma and lung carcinoma cell lines. The FOXQ1 gene is located on chromosome 6p23-25. Databank analysis shows 82% homology with the mouse Foxq1 gene (formerly Hfh-1L) and with a revised sequence of the rat FoxQ1 gene (formerly HFH-1). The DNA-binding motif, named HNF-3/forkhead domain, is well conserved, showing 100% identity in human, mouse, and rat. The human protein sequence contains two putative transcriptional activation domains, which share a high amino acid identity with the corresponding mouse and rat domains.
ACCESSION #
5493287

 

Related Articles

  • Can enhancement be distinguished from prevention in genetic medicine? Juengst, Eric T. // Journal of Medicine & Philosophy;Apr97, Vol. 22 Issue 2, p125 

    Discusses the ethics of human gene transfer as it relates to the philosophy of medicine. Use of human gene transfer techniques to treat health problems; Impact on the normal human traits; Disputes over the normative force of this distinction; Arguments that a line should be drawn between...

  • The first 25 years of human genetics in Newcastle. Papiha, S.S. // Human Biology;Oct96, Vol. 68 Issue 5, p603 

    Focuses on the history of human genetics in Newcastle, England. Development of a human genetics department by the late professor D.F. Roberts; Teaching of human genetics.

  • Did a gene make him do this?  // Current Science;4/19/96, Vol. 81 Issue 16, p14 

    Reports that researchers of Israel and the United States discovered a gene which suggested that thrill seeking behavior can be inherited. Findings of the researchers; What findings were based on; Comments from Jonathan Benjamin, who co-authored the study.

  • That's Me. Wiese, Jim // Cricket;Mar2001, Vol. 28 Issue 7, p45 

    Offers instructions on how to analyze your genes by looking at you physical traits compared with those of your parents.

  • Twins spring gene shocker. Holmes, Bob // New Scientist;06/14/97, Vol. 154 Issue 2086, p16 

    Presents the results of a study on the role of genes in determining man's mental abilities in later life, as conducted by London Institute of Psychiatry behavioral genetist Robert Plomin. Factors that affect mental abilities; Increase of genetic contribution to mental abilities with age.

  • From genes for intelligence to our understanding of genes. Darlu, Pierre // Diogenes;1997, Vol. 45 Issue 180, p21 

    Provides information on the history and development of human genetics. Debates on the role of social or biological heredity in the expression of criminality, mental retardation or intelligence; Who discovered the first human blood typing called the ABO system; Information on the chromosome...

  • TOUCHINGbase.  // Nature Genetics;Sep98, Vol. 20 Issue 1, p11 

    Reports on developments in human genetics in the United States as of September 1998. National Cancer Institute's launching of the Cancer Chromosome Aberration Project; Jackson Laboratory's annual summer course on mammalian genetics in Maine; Animated Biomedical Productions release of the video...

  • TP53haplotype-based analysis and incidence of post-angioplasty restenosis. Zee, Robert; Cook, Nancy; Kim, Chung-Ah; Fernandez-Cruz, Arturo; Lindpaintner, Klaus // Human Genetics;Nov2004, Vol. 115 Issue 6, p530 

    Presents a correction to the article "TP53 Haplotype-Based Analysis and Incidence of Post-Angioplasty Restenosis," previously published in the journal "Human Genetics."

  • Composite measure of linkage disequilibrium for testing interaction between unlinked loci. Xuesen Wu; L. Jin; Momiao Xiong // European Journal of Human Genetics;Sep2008, Vol. 16 Issue 9, p1160 

    A correction to the article "Composite measure of linkage disequilibrium for testing interaction between unlinked loci" is presented.

  • Reply to Rational drug repositioning by medical genetics. Sanseau, Philippe; Agarwal, Pankaj; Barnes, Michael R; Pastinen, Tomi; Richards, J Brent; Cardon, Lon R; Mooser, Vincent // Nature Biotechnology;Dec2013, Vol. 31 Issue 12, p1082 

    A response from the author of an article published in the previous issue is presented, which discusses the evidence that human genetics can be used to identify drug repositioning and focuses on the significance of understanding the functional impact of genetic variation.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics