TITLE

PAW15 Screening patients with a family history of subarachnoid haemorrhage for intracranial aneurysms: screening uptake, patient characteristics and outcome

AUTHOR(S)
T Miller
PUB. DATE
November 2010
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Nov2010, Vol. 81 Issue 11, pe28
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
BACKGROUND: People with ≥1 first degree relative affected (FDRA) by aneurismal subarachnoid haemorrhage (SAH) are at higher lifetime risk of SAH than those without a family history. Screening may be worthwhile for people with ≥2 FDRA by aneurismal SAH, but its clinical effectiveness is not established beyond doubt. METHODS: We performed a retrospective, observational analysis of consecutive attendances at an aneurysm screening clinic between October 2006 and June 2009. RESULTS: Of 96 adults seen, 77 had ≥1 FDRA: 35 had ≥2 FDRA, 21 had 1 FDRA plus ≥1 affected second degree relative, and 21 had 1 FDRA only. In these three respective groups, 29 (83%), 15 (71%) and 5 (24%) adults underwent screening (p<0.0001), of whom 6 (21%), 3 (20%) and 1 (20%) had an aneurysm detected (p=1.0). Of the 10 patients with aneurysms, four underwent treatment. Considering other risk factors adults with ≥2 FDRA were more likely to be hypertensive (OR 4.1, 95% CI 1.2 to 13.4) but no more likely to smoke or drink to excess than adults with 1 FDRA. Adults who underwent screening were more likely to be hypertensive and drink alcohol to excess (both p<0.0001) but not more likely to smoke than those who were not screened. CONCLUSION: In clinical practice, aneurysm screening uptake increases with number of relatives affected by SAH and is associated with modifiable risk factors for SAH.
ACCESSION #
54845768

 

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