TITLE

HYPOTENSIVE AND CARDIOINHIBOTORY EFFECTS OF THE AQUEOUS AND ETHANOL EXTRACTS OF CELERY (APIUM GRAVEOLENS, APIACEAE)

AUTHOR(S)
Branković, Suzana; Kitić, Dušanka; Radenković, Mirjana; Veljković, Slavimir; Kostić, Milica; Miladinović, Bojana; Pavlović, Dragana
PUB. DATE
March 2010
SOURCE
Acta Medica Medianae;Mar2010, Vol. 49 Issue 1, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In this study, we present the effects of aqueous and ethanol extracts of celery (Apium graveolens, Apiaceae) investigated on the mean blood pressure of anaesthetized rabbits and contractility of isolated atria of the rats. In our experiments, the rabbits and Wistar albino rats were used. The effects of extracts (0.5-15 mg/kg) on blood pressure were recorded directly from the carotid artery. Isolated rat atria were mounted in 10 ml tissue bath. An equilibrium period of 30 min was given before the application of the extracts (0.02-0.75mg/ml). In anesthetized rabbit, intravenous administration of aqueous extracts induced least hypotensive effects (14.35±2.94%), while the ethanol extract caused the greatest fall in the blood pressure (45.79±10.86%). Hypotensive effects of the extracts were partially blocked by atropine (0.3 mg/kg), an unselective muscarinic receptor antagonist. In isolated rat atria, both aqueous and ethanol extracts of celery exhibit a negative chronotropic and inotropic actions. Aqueous extract decreased the rate of contractions by 12.88±2.74% and amplitude by 8.73±0.89%. Ethanol extract inhibited the rate of atria contractions by 34.26±5.69% and amplitude by 25.40±3.61%. Pretreatment rat atria with atropine (1 μM) partially blocked inhibitory response of aqueous and ethanol extracts. Ethanol extract of celery significantly exhibited greater hypotensive and cardio-depressant activities compared to aqueous extract (p<0.05). These data suggest that both aqueous and ethanol extracts of celery caused the hypotensive, negative inotropic and chronotropic effects, which could partially be mediated via stimulation of muscarinic receptors. Inhibitory effect of ethanol extract was significant compared to aqueous extract of celery.
ACCESSION #
54710403

 

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