TITLE

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

AUTHOR(S)
Baeza, José Luis; Bonache, M. Á ngeles; García-López, M. Teresa; González-Muñiz, Rosario; Martín-Martínez, Mercedes
PUB. DATE
November 2010
SOURCE
Amino Acids;Nov2010, Vol. 39 Issue 5, p1299
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as reverse turn inducers (γ- vs. β-turns). Despite the presence of an Asp residue at i position, highly preferred in β-turns, molecular modeling and NMR studies indicated that the azetidine-containing peptides mainly stabilized γ-turn conformations.
ACCESSION #
54600159

 

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