TITLE

The inflammatory response to CPB: the role of leukocyte filtration

AUTHOR(S)
Asimakopoulos, George
PUB. DATE
March 2002
SOURCE
Perfusion;Mar2002 Supplement, Vol. 17 Issue 2S, p7
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Leukocyte activation is a significant component of the systemic inflammatory response to cardiopulmonary bypass (CPB). Various strategies have been developed aiming to reduce leukocyte activation and its deleterious effects on organ function after cardiac surgery. Leukocyte filtration aims to physically remove activated leukocytes from the circulation during CPB. The technique has been used since the mid-1990s but its efficacy in attenuating the effects of inflammatory response remains controversial. This article presents a review of published trials investigating the effects of leukocyte filtration on humans undergoing cardiac surgery.
ACCESSION #
54537882

 

Related Articles

  • The inflammatory response to CPB: the role of leukocyte filtration. Asimakopoulos, George // Perfusion;May2002 Supplement 1, Vol. 17, p7 

    Examines the role of leukocyte filtration on the inflammatory response to cardiopulmonary bypass (CPB). Reduction of leukocyte activation and deleterious effects on organ function following cardiac surgery; Controversy on the efficacy of CPB in attenuating the effects of inflammatory response;...

  • Leukocyte Depletion During CPB: Effects on Inflammation and Lung Function. Amorim, Célio; Malbouisson, Luiz; Silva, Francisco; Fiorelli, Alfredo; Murakami, Caroline; Carmona, Maria // Inflammation;Feb2014, Vol. 37 Issue 1, p196 

    Cardiopulmonary bypass (CPB) is related to inflammatory response and pulmonary dysfunction. The aim of this study was to evaluate the effects of CPB leukocyte filtration on inflammation and lung function after coronary artery bypass grafting (CABG). A prospective randomized study was performed...

  • Cardiopulmonary bypass induced microcirculatory injury of the small bowel in rats. Guo-Hua Dong; Chang-Tian Wang; Yun Li; Biao Xu; Jian-Jun Qian; Hai-Wei Wu; Hua Jing; Tsuji, Shingo // World Journal of Gastroenterology;7/7/2009, Vol. 15 Issue 25, p3166 

    AIM: To investigate microvascular injury quantitatively in the small bowel with respect to cardiopulmonary bypass (CPB) and related mechanisms. METHODS: In 10 male SD rats, normothermic CPB was established and continued with a flow rate of 100-150 mL/kg per minute for 60 min, while another 10...

  • Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass. Olivencia-Yurvati, AH; Ferrara, CA; Tierney, N; Wallace, N; Mallet, RT // Perfusion;Jan2003 Supplement, Vol. 18, p23 

    Cardiopulmonary bypass (CPB) precipitates inflammation that causes marked pulmonary dysfunction. Leukocyte filtration has been proposed to reduce these deleterious effects. Other studies show an improvement with aprotinin. We proposed that a combination of these two therapies would...

  • The last molecular fortress in leukocyte trans-endothelial migration. Aurrand-Lions, Michel; Johnson-Leger, Caroline; Imhof, Beat A. // Nature Immunology;Feb2002, Vol. 3 Issue 2, p116 

    Discusses the role of junction adhesion molecule 1 (JAM-1) and CD99 in transendothelial migration. Participation of leukocytes in inflammatory responses of the immune system; Manipulation of leukocyte transmigration through inflammatory stimulation of endothelial cells; Facilitation of...

  • The GP IIb/IIIa inhibitor abciximab (ReoPro®) decreases activation and interaction of platelets and leukocytes during in vitro cardiopulmonary bypass simulation Straub, Andreas; Wendel, Hans Peter; Azevedo, Ruben; Ziemer, Gerhard // European Journal of Cardio-Thoracic Surgery;Apr2005, Vol. 27 Issue 4, p617 

    Abstract: Objective: Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and increases expression of the platelet activation marker P-selectin which mediates binding of platelets to leukocytes. Inhibition of the platelet GP IIb/IIIa receptor during CPB has been shown to protect...

  • The intraoperative effect of pentoxifylline on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass. Ça&gcaron;lι, Kerim; Ulaş, Mahmut Mustafa; Özιşιk, Kanat; Kale, Arzum; Bakuy, Vedat; Emir, Mustafa; Balcι, Mustafa; Topbaş, Murat; Şener, Erol; Taşdemir, O&gcaron;uz // Perfusion;Jan2005, Vol. 20 Issue 1, p45 

    Background: Inflammation plays a pivotal role in the pathogenesis of organ dysfunction after cardiopulmonary bypass (CPB). The aim of this study was to investigate whether pentoxifylline (PTX) has effects on the inflammatory process and leukocytes in cardiac surgery patients undergoing CPB....

  • Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. Song, Jason J.; Hwang, Inyong; Cho, Kyung H.; Garcia, Michael A.; Kim, Arthur J.; Wang, Tiffany H.; Lindstrom, Tamsin M.; Lee, Annette T.; Nishimura, Toshihiko; Zhao, Lei; Morser, John; Nesheim, Michael; Goodman, Stuart B.; Lee, David M.; Bridges, S. Louis; Gregersen, Peter K.; Leung, Lawrence L.; Robinson, William H.; Bridges, S Louis Jr; Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry // Journal of Clinical Investigation;Sep2011, Vol. 121 Issue 9, p3517 

    The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase B (CPB), which is activated by the thrombin/thrombomodulin complex, plays a procoagulant role during fibrin clot formation. However, an antiinflammatory role for CPB...

  • Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update Paparella, D.; Yau, T.M.; Young, E. // European Journal of Cardio-Thoracic Surgery;Feb2002, Vol. 21 Issue 2, p232 

    Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis of several postoperative complications. Recent data indicate that a complex sequence of events leads to the final activation of leukocytes and endothelial cells (EC),...

Share

Other Topics