TITLE

The role of leukodepletion in limiting ischemia/reperfusion damage in the heart, lung and lower extremity

AUTHOR(S)
Allen, Bradley S
PUB. DATE
March 2002
SOURCE
Perfusion;Mar2002 Supplement, Vol. 17 Issue 2S, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article describes the experimental infrastructure and subsequent clinical application of a comprehensive reper-fusion strategy to limit the injury following ischemia, resulting in an improvement in post operative organ function. In particular, it examines the role of luekodepletion in minimizing damage and improving functional outcome in the heart, lung and lower extremity. During cardiothoracic procedures, various organs can be subjected to temporary ischemia, particularly the heart (cardioplegic arrest), lung (transplant), and lower extremity (femoral canulation, IABP). The background of ischemia/reperfusion injury is discussed as it applies to each of these 3 organs, as well as findings that ischemia followed by reperfusion results in a similar injury in each organ. Data are then presented to demonstrate that a comprehensive reperfusion strategy, utilizing a modified substrate-enriched blood reperfusatedeliveredat a low pressure can limit this injury, and that adding white blood cell filtration significantly improves the efficacy of this approach. These principles have now been used in a series of patients undergoing various surgical procedures with excellent results. Applicationof theseconcepts may significantlyimprove theoutcome in patients undergoing procedures which subject these organs to temporary ischemia.
ACCESSION #
54537876

 

Related Articles

  • The role of leukodepletion in limiting ischemia/reperfusion damage in the heart, lung and lower extremity. Allen, BS // Perfusion;May2002 Supplement 1, Vol. 17, p11 

    This article describes the experimental infrastructure and subsequent clinical application of a comprehensive reperfusion strategy to limit the injury following ischemia, resulting in an improvement in post operative organ function. In particular, it examines the role of luekodepletion in...

  • Dual roles of 5-hydroxytryptamine in ischemia-reperfusion injury in isolated rat hearts. Takano, Shizuko; Hoshino, Yuji; Libing Li; Matsuoka, Isao; Ono, Tomoyuki; Kimura, Jiinko; Li, Libing; Kimura, Junko // Journal of Cardiovascular Pharmacology & Therapeutics;Mar2004, Vol. 9 Issue 1, p43 

    Background: 5-Hydroxytryptamine (5-HT) has been shown to be involved in exacerbating cardiac ischemia-reperfusion injury; however, the role of 5-HT in the injury has yet to be established. This study demonstrates that 5-HT has dual roles in ischemia-reperfusion injury.Methods...

  • Role of nitric oxide in the functional response to ischemia-reperfusion of heart mitochondria from hyperthyroid rats. Venditti, P.; De Rosa, R.; Cigliano, L.; Agnisola, C.; Di Meo, S. // Cellular & Molecular Life Sciences;Sep2004, Vol. 61 Issue 17, p2244 

    We investigated the role of nitric oxide (NO) in the mitochondrial derangement associated with the functional response to ischemia-reperfusion of hyperthyroid rat hearts. Mitochondria were isolated at 3000 g from hearts subjected to ischemia-reperfusion, with or without Nω-nitro-L-arginine...

  • Autophagy and Heart Disease: Implications for Cardiac Ischemia- Reperfusion Damage. Ghavami, S.; Gupta, S.; Ambrose, E.; Hnatowich, M.; Freed, D. H.; Dixon, I. M. C. // Current Molecular Medicine;Jun2014, Vol. 14 Issue 5, p616 

    Survival of myocytes and mesenchymal cells in the heart is tightly regulated by a number of adaptive processes that are invoked with the changes that occur within the parenchyma and stroma. Autophagy is implicated in cellular housekeeping duties and maintenance of the integrity of the...

  • Ischemia-Reperfusion Lung Injury Is Attenuated in MyD88-Deficient Mice. Altemeier, William A.; Liles, W. Conrad; Villagra-Garcia, Ana; Matute-Bello, Gustavo; Glenny, Robb W. // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Ischemia-reperfusion lung injury is a common cause of acute morbidity and mortality in lung transplant recipients and has been associated with subsequent development of bronchiolitis obliterans syndrome. Recognition of endogenous ligands released during cellular injury (damage-associated...

  • Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke). Bakeeva, L. E.; Barskov, I. V.; Egorov, M. V.; Isaev, N. K.; Kapelko, V. I.; Kazachenko, A. V.; Kirpatovsky, V. I.; Kozlovsky, S. V.; Lakomkin, V. L.; Levina, S. B.; Pisarenko, O. I.; Plotnikov, E. Y.; Saprunova, V. B.; Serebryakova, L. I.; Skulachev, M. V.; Stelmashook, E. V.; Studneva, I. M.; Tskitishvili, O. V.; Vasilyeva, A. K.; Victorov, I. V. // Biochemistry (00062979);Dec2008, Vol. 73 Issue 12, p1288 

    Effects of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) and 10-(6′-plastoquinonyl) decylrhod-amine 19 (SkQR1) on rat models of H2O2- and ischemia-induced heart arrhythmia, heart infarction, kidney ischemia, and stroke have been studied ex vivo and in vivo. In all the...

  • Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Reiter, Russel J.; Tan, Dun-Xian // Cardiovascular Research;Apr2003, Vol. 58 Issue 1, p10 

    This brief review summarizes the recently obtained evidence which illustrates the beneficial effects of the endogenously produced antioxidant, melatonin, in reducing tissue damage and reversing cardiac pathophysiology in models of experimental ischemia/reperfusion. The report also describes the...

  • Heartsick America. Cowley, Geoffrey // Bulletin with Newsweek;05/29/2001, Vol. 119 Issue 6276, p96 

    Reports on the National Heart, Lung & Blood Institute study on the effect of lowering high blood cholesterol levels on the risk of coronary heart disease. Low density lipoprotein (LDL) limits recommended for different groups of people; Usefulness of drugs in preventing heart attacks by lowering...

  • Excess exercise 'hurts the heart'.  // Daily Mail;6/4/2012, p32 

    EXTREME exercise such as marathon running may permanently damage the heart, warn researchers.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics