Determination of diltiazem based on the reduction of Cu(ll)-BCA complexes in micellar medium

Sabino, Larissa Zuppardo Lacerda; Marino, Daniele Cestari; Moya, Horacio Dorigan
June 2010
Canadian Journal of Chemistry;Jun2010, Vol. 88 Issue 6, p533
Academic Journal
A simple method was developed for determining microquantities of diltiazem. based on the reduction of copper(II) in buffered solution (pH 7.0) and the use of a micellar medium containing 4,4′-dicarhoxy-2,2′-biquinoline acid. The copper(I) produced reacts with 4,4′-dicarboxy-2,2′-biquinoline acid and the complexes formed are spectrophotometrically measured at 558 nm. A typical calibration graph shows good linearity (r = 0.993) from 20 to 100 µg mL-1 of diltiazem. The limit of detection and relative standard deviation were calculated as 12 µg mL-1 (99% confidence level) and 3 .5% (40 µg mL-1; n = 6). respectively, with a mean recovery value of 96.5% found in pharmaceutical dosages. A straightforward and effective way to recycle the reagents is addressed. The hazardous aspects of the Cu(I)-BCA reaction are presented as well.


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