TITLE

Leucodepletion and the interaction of polymorphonuclear cells with endothelium in systemic inflammatory response syndrome

AUTHOR(S)
Brown, K A; Lewis, S M; Hill, T A; Macey, M G; McCarthey, D A; Grant, V A; Treacher, D F
PUB. DATE
January 2001
SOURCE
Perfusion;Jan2001 Supplement, Vol. 16 Issue 1S, p75
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The abnormal interaction of polymorphonuclear cells (PMNs) with blood vessel walls is considered to underlie the multiple organ failure of systemic inflammatory response syndrome (SIRS). This consideration is supported by the present finding that PMNs from patients with SIRS are activated, as assessed by an increased distribution of cells bearing CD64, enhanced expression of CD11b and decreased expression of CD62L, and are highly adhesive to endothelial monolayers. Passage of SIRS blood through leucodepletion filters in a laboratory-designed extracorporeal circuit resulted in a marked depletion of PMNs. Of the PMNs that remained in the blood, far fewer cells bound to cultured endothelial cells in comparison with PMNs prior to leucofiltration. We propose that leucofiltration of SIRS blood will limit the number of PMNs available for binding to blood vessel walls and, hence, reduce the pathological manifestations associated with this disorder.
ACCESSION #
54384584

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics