TITLE

Asymmetric conjugate addition of ketones to nitroalkenes catalyzed by chiral bifunctional sulfamides

AUTHOR(S)
Sheng-ping Liu; Xue-jing Zhang; Jin-hua Lao; Ming Yan
PUB. DATE
January 2009
SOURCE
ARKIVOC: Online Journal of Organic Chemistry;2009, p268
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Chiral bifunctional sulfamides were found to be efficient catalysts for the conjugate addition of ketones to nitroalkenes. Moderate to good enantioselectivities and yields were achieved for the reaction of acetone with a variety of β-aryl-nitroethylenes. Base additives were found to be more efficient than acid additives for the transformation. The reaction of methoxyacetone and cyclopentanone also provided the adducts with moderate enantioselectivities, however in low chemical yields.
ACCESSION #
54321108

 

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