TITLE

Design issues in cancer screening trials

AUTHOR(S)
Moss, Sue
PUB. DATE
October 2010
SOURCE
Statistical Methods in Medical Research;Oct2010, Vol. 19 Issue 5, p451
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Randomised controlled trials avoid many of the potential biases associated with the evaluation of cancer screening. Nevertheless there are many issues concerning the design of such trials that require careful consideration and that will influence interpretation of the results. This article discusses issues related to recruitment and randomisation, which will affect the extent to which the population studied, is representative of the eventual target population of a screening programme. It addresses sample size considerations, the use of appropriate outcome measures and the timing of the intervention. Finally, issues related to ensuring appropriate analyses are discussed.
ACCESSION #
54289362

 

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