TITLE

Stilboestrol and vaginal clear-cell adenocarcinoma syndrome

AUTHOR(S)
Monaghan, John M.; Sirisena, L.A.W.
PUB. DATE
June 1978
SOURCE
British Medical Journal;6/17/1978, Vol. 1 Issue 6127, p1588
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A vaginal clear-cell adenocarcinoma developed in a young woman who had been exposed in utero to maternal stilboestrol treatment. During 1940-71 in the UK some 7500 women were given stilboestrol during pregnancy. Thus more cases are likely to appear and clinicians caring for young women should be alert to this possibility.
Stilboestrol has long been incriminated as a transplacental carcinogen. The pathogenesis of these processes is unknown. Ingestion of oestrogen in the first 18 weeks of pregnancy is thought to prevent squamous metaplasia of glandular epithelium in the upper fetal vagina, so that at puberty the ovarian hormones stimulate the persisting glandular epithelium, causing abnormal proliferation. During the 1940s-60s stilboestrol was used in some British centres to support high-risk pregnancies.
ACCESSION #
5418350

 

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