TITLE

Rifaximin maintained remission from hepatic encephalopathy longer than placebo in patients with cirrhosis

AUTHOR(S)
Story, Brian T.; Kowdley, Kris V.
PUB. DATE
August 2010
SOURCE
ACP Journal Club;8/17/2010, Vol. 153 Issue 2, p7
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on a study focusing on the effectiveness of rifaximin in comparison to placebos in cirrhosis patients who are in remission from hepatic encephalopathy. The findings of the study indicate that rifaximin increased the time for first breakthrough episode of hepatic encephalopathy and maintained remission longer than placebo. However, as stated it is a minimally absorbed antibiotic and more studies are needed to evaluate strategies for management of hepatic encephalopathy.
ACCESSION #
54115051

 

Related Articles

  • Hyperion Therapeutics' Glycerol Phenylbutyrate Meets Primary Endpoint in Phase II Study in Episodic Hepatic Encephalopathy.  // Biomedical Market Newsletter;6/7/2012, Vol. 21, p1 

    The article informs that Hyperion Therapeutics Inc.'s phase II study of glycerol phenylbutyrate, an investigational drug for the treatment of episodic hepatic encephalopathy (HE) has met its primary endpoint. The results from the study showed that the proportion of patients experiencing at least...

  • Higher Grades and Repeated Recurrence of Hepatic Encephalopathy May Be Related to High Serum Manganese Levels. Kobtan, Abdelrahman; El-Kalla, Ferial; Soliman, Hanan; Zakaria, Soha; Goda, Mohamed // Biological Trace Element Research;Feb2016, Vol. 169 Issue 2, p153 

    Hepatic encephalopathy is a serious complication of liver failure. Until now, the precise pathophysiologic mechanisms are not fully determined. It has been demonstrated that manganese plays an important role in the pathogenesis of hepatic encephalopathy. Therefore, we studied manganese levels in...

  • Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials. Als-Nielsen, Bodil; Gluud, Lise L.; Gluud, Christian // BMJ: British Medical Journal (International Edition);5/1/2004, Vol. 328 Issue 7447, p1046 

    Objective To assess the effects of non-absorbable disaccharides (lactulose and lactitol) in patients with hepatic encephalopathy. Data sources Cochrane Hepato-Biliary Group controlled trials register, Cochrane Library, Medline, and Embase until March 2003; reference lists of relevant articles;...

  • The Relative Contribution of Hepatic Encephalopathy to Burden in Patients With Cirrhosis. Parikh, Neehar; Butt, Zeeshan // American Journal of Gastroenterology;Mar2012, Vol. 107 Issue 3, p486 

    A letter to the editor is presented in response to the article "The multidimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers," by J. S. Bajaj and colleagues in the 2011 issue.

  • Editorial: Rifaximin and Minimal Hepatic Encephalopathy. Butterworth, Roger F. // American Journal of Gastroenterology;Feb2011, Vol. 106 Issue 2, p317 

    Minimal hepatic encephalopathy (MHE) occurs in up to 70% of patients with cirrhosis and has a clear impact on health-related quality of life (HRQOL) in these patients. Antibiotics leading to reductions in circulating ammonia have been used in the past for the treatment of MHE. However, serious...

  • Diagnosis and treatment of hepatic encephalopathy. Savlan, Ilona; Liakina, Valentina; Valantinas, Jonas // Acta Medica Lituanica;2013, Vol. 20 Issue 1, p1 

    Background. Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver cirrhosis which symptoms may vary from imperceptible to severe ones. In recent years, there have been some changes of fundamental hepatic encephalopathy pathogenesis and treatment. The early HE on the stage of...

  • Serum macrophage inflammatory protein 3α levels predict the severity of HBV-related acute-on-chronic liver failure. Jiaojiao Xin; Wenchao Ding; Shaorui Hao; Xin Chen; Jianing Zhang; Longyan Jiang; Qian Zhou; Dongyan Shi; Liyuan Zhang; Xiaowei Xu; Hongcui Cao; Lanjuan Li; Jun Li // Gut;Feb2016, Vol. 65 Issue 2, p355 

    A letter to the editor is presented in response to the article "Acute Kidney Injury and Acute-on-Chronic Liver Failure Classifications in Prognosis Assessment of Patients With Acute Decompensation of Cirrhosis," by P. Angeli et al published in a 2015 issue.

  • Management of acute-on-chronic liver failure: rotational thromboelastometry may reduce substitution of coagulation factors in liver cirrhosis. Bedreli, Sotiria; Sowa, Jan-Peter; Gerken, Guido; Hakan Saner, Fuat; Canbay, Ali // Gut;Feb2016, Vol. 65 Issue 2, p357 

    A letter to the editor is presented in response to the article "Acute Kidney Injury and Acute-on-Chronic Liver Failure Classifications in Prognosis Assessment of Patients With Acute Decompensation of Cirrhosis," by P. Angeli et al published in a 2015 issue.

  • Management of hepatic encephalopathy.  // British Medical Journal (Clinical Research Edition);1/17/1981, Vol. 282 Issue 6259, p171 

    Focuses on the management of hepatic encephalopathy in patients with liver failure. Disturbances in hepatic encephalopathy; Patterns of hepatic encephalopathy; Treatment for controlling encephalopathy.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics