Low-dose computed tomography was associated with higher risk for false-positive lung cancer screening than chest radiography

Stanbrook, Matthew B.
August 2010
ACP Journal Club;8/17/2010, Vol. 153 Issue 2, p4
Academic Journal
The article focuses on a study comparing the effectiveness of chest radiography (CXR) with low-dose computed tomography (CT) in diagnosing lung cancer patients, conducted by J. M. Croswell and colleagues. It discusses the methodology adopted during the study including the follow-up period, age group of patients, and the employed medical screening procedures. It reports that the study found more false-positive results by the use of CT than CXR, and comments upon the implications of its findings.


Related Articles

  • From randomized trials to the clinic: is it time to implement individual lung-cancer screening in clinical practice? A multidisciplinary statement from French experts on behalf of the french intergroup (IFCT) and the groupe d'Oncologie de langue ... Couraud, S.; Cortot, A. B.; Greillier, L.; Gounant, V.; Mennecier, B.; Girard, N.; Besse, B.; Brouchet, L.; Castelnau, O.; Frappé, P.; Ferretti, G. R.; Guittet, L.; Khalil, A.; Lefebure, P.; Laurent, F.; Liebart, S.; Molinier, O.; Quoix, E.; Revel, M.-P.; Stach, B. // Annals of Oncology;Mar2013, Vol. 24 Issue 3, p586 

    Background Despite advances in cancer therapy, mortality is still high except in early-stage tumors, and screening remains a challenge. The randomized National Lung Screening Trial (NLST), comparing annual low-dose computed tomography (LDCT) and chest X-rays, revealed a 20% decrease in...

  • The utility of routine tuberculosis screening in county hospital patients with uveitis. Bryan Kun Hong; Khanamiri, Hossein Nazari; Bababeygy, Simon R.; Rao, Narsing A. // British Journal of Ophthalmology;Aug2014, Vol. 98 Issue 8, p1091 

    Background/aim To evaluate the utility of tuberculosis (TB) screening in diagnosing ocular TB in uveitis patients in a government-funded hospital. Methods The charts of 142 consecutive patients seen during August 2011-July 2012 at the Los Angeles County Hospital uveitis clinic were reviewed for...

  • Early Detection of Lung Cancer Using CT Scan and Bronchoscopy in a High Risk Population. Jayaprakash, Vijayvel; Loewen, Gregory M.; Dhillon, Samjot S.; Moysich, Kirsten B.; Mahoney, Martin C.; Yendamuri, Sai; Hogarth, D. Kyle; Reid, Mary E. // Journal of Cancer Therapy;Aug2012 Supplement, Vol. 3 Issue 4A, p388 

    Background: Computed tomography (CT) and bronchoscopy have been shown to improve the detection rates of peripheral and central lung cancers (LC), respectively. However, the performance of the combination of CT and bronchoscopy in detecting LC, in high-risk patients, is not clear. Patients &...

  • Long-term follow-up of non-calcified pulmonary nodules (<10 mm) identified during low-dose CT screening for lung cancer. Slattery, Michael; Foley, Claire; Kenny, Dermot; Costello, Richard; Logan, P.; Lee, Michael // European Radiology;Sep2012, Vol. 22 Issue 9, p1923 

    Objectives: To assess the long-term stability of small (<10 mm) non-calcified pulmonary nodules (NCNs) in high-risk subjects initially screened for lung cancer using low-dose chest computed tomography (LDCCT). Methods: A total of 449 subjects initially underwent screening with serial LDCCT over...

  • Screening by Chest Radiograph and Lung Cancer Mortality. Oken, Martin M.; Hocking, Willam G.; Kvale, Paul A.; Andriole, Gerald L.; Buys, Saundra S.; Church, Timothy R.; Crawford, E. David; Fouad, Mona N.; Isaacs, Claudine; Reding, Douglas J.; Weissfeld, Joel L.; Yokochi, Lance A.; O'Brien, Barbara; Ragard, Lawrence R.; Rathmell, Joshua M.; Riley, Thomas L.; Wright, Patrick; Caparaso, Neil; Ping Hu; Izmirlian, Grant // JAMA: Journal of the American Medical Association;11/2/2011, Vol. 306 Issue 17, p1865 

    The article discusses a study of the effect on mortality of screening for lung cancer (LC) using modern chest radiographs (CR). The authors invited 154,901 participants aged 55 through 74 years, who were randomized to intervention group (IG) and to usual care group (UCG). Participants in the IG...

  • Screening for Lung Cancer With Chest Radiographs. Sox, Harold C. // JAMA: Journal of the American Medical Association;11/2/2011, Vol. 306 Issue 17, p1916 

    The author discusses a study published within the issue about the National Cancer Institute-sponsored Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Randomized Trial which assessed the effect on mortality of screening for lung cancer (LC) using modern chest radiography (CR). He expresses...

  • Patients' preferences about follow-up of medium size polyps detected at screening CT colonography. Neri, Emanuele; Faggioni, Lorenzo; Vagli, Paola; Cerri, Francesca; Picano, Eugenia; Angeli, Simone; Cini, Lorenzo; Bartolozzi, Carlo // Abdominal Imaging;Nov/Dec2011, Vol. 36 Issue 6, p713 

    Purpose: To evaluate patients' preferences regarding follow-up of medium size polyps detected at screening CT colonography (CTC). Methods and Materials: 193 C-RADS2 asymptomatic patients were asked to fill in a form explaining the indications, technique and potential...

  • False-positive results common with chest X-ray, CT scan after two lung cancer screenings.  // Hem/Onc Today;5/10/2010, Vol. 11 Issue 9, p36 

    The article discusses research on the probability of one or more false-positive low-dose computed tomography (CT) and chest radiography results following two lung cancer screenings, published in a 2010 issue of the "Annals of Internal Medicine."

  • ANTÄ°-TNF-ALFA TEDAVÄ°SÄ° VERÄ°LEN OLGULARDA LATENT TÃœBERKÃœLOZ Ä°NFEKSÄ°YONU AÇISINDAN Ä°ZLEM SONUÇLARIMIZ. Mutlu, Pınar; Sevinç, Can; Kılınç, Oğuz; Uçan, Eyüp Sabri // Nobel Medicus Journal;Jan-Apr2014, Vol. 10 Issue 1, p47 

    Objective: This study was planned to evaluate our approach to latent tuberculosis infection in patients who are given anti-tumor necrosis factor-α (TNF-α) therapy. Material and Method: Observation results of 196 patients who were given anti-TNF-α therapy and between August 2005 and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics