2010 - Review: Statins do not reduce mortality in patients with no history of cardiovascular disease

Maron, David J.
September 2010
ACP Journal Club;9/21/2010, Vol. 153 Issue 3, p3
Academic Journal
The article presents a study establishing whether statins reduce mortality in patients with no cardiovascular disease (CVD) history. According to random control trials (RCT) and meta-analysis by K. K. Ray and colleagues statins or Anticholesteremic agents do not reduce mortality in patients with no CVD history. A comparison chart for statins and mortality rate in high-risk patients with no history of CVD, is also presented.


Related Articles

  • Early, intensive statin therapy reduces risk of death and cardiac events in patients hospitalized for ACS.  // Formulary;Nov2006, Vol. 41 Issue 11, p576 

    The article presents information on a meta-analysis of intensive statin therapy. The researchers including Eddie Hulten concluded that intensive statin therapy administered to patients within 14 days of hospitalization for acute coronary syndrome can reduce the risk of death and certain...

  • DYSLIPIDEMIA DRUG INDICATIONS.  // Monthly Prescribing Reference;Jul2013, Vol. 29 Issue 7, p25 

    A table is presented which provides information on various drugs used for the treatment of dyslipidemias including bile acid sequestrants, cholesterol absorption inhibitor and statins.

  • Statins for all patients with diabetes? Kirchner, Jeff; Russell, John J. // Patient Care;Aug2003, Vol. 37 Issue 8, p68 

    Discusses research being done on statin as treatment for patients with diabetes. Reference to a study by R. Collins et al published in the 2003 issue of "Lancet"; Explanation on diabetes; Findings of the study.

  • Controversial concerns over relative rosuvastatin safety.  // Reactions Weekly;6/4/2005, Issue 1054, p3 

    Discusses research being done on the safety of rosuvastatin, a statin used in common clinical practice. Reference to a study by A. A. Alsheikh-Ali et al published in the 2005 issue of "Circulation"; Findings of the study.

  • 2008 - Review: Statins prevent stroke and reduce mortality. Hankey, Graeme J. // ACP Journal Club;7/15/2008, Vol. 149 Issue 1, p6 

    The article presents a study that was conducted by E.J. Mills and colleagues, whether statins prevent stroke and reduce mortality in adults. The study compared a statin with placebo or no treatment. Meta-analysis showed that statins were more effective than placebo or no treatment for reducing...

  • Effect of Statins on Venous Thromboembolic Events: A Meta-analysis of Published and Unpublished Evidence from Randomised Controlled Trials. Rahimi, Kazem; Bhala, Neeraj; Kamphuisen, Pieter; Emberson, Jonathan; Biere-Rafi, Sara; Krane, Vera; Robertson, Michele; Wikstrand, John; McMurray, John // PLoS Clinical Trials;Sep2012, Vol. 7 Issue 9, p1 

    A systematic review and meta-analysis conducted by Kazem Rahimi and colleagues re-evaluates the hypothesis, generated in previous studies, that statins may reduce the risk of venous thromboembolic events. Their meta-analysis does not support the previous findings.

  • Efficacy and Safety of Statin Monotherapy in Older Adults: A Meta-Analysis. Roberts, Caroline G. P.; Guallar, Eliseo; Rodriguez, Annabelle // Journals of Gerontology Series A: Biological Sciences & Medical ;Aug2007, Vol. 62A Issue 8, p879 

    Background. Statin therapy significantly reduces cardiovascular events. Older patients, however, are less likely to be prescribed statins than younger patients due to concern over lack of indication, lower predictive value of cholesterol levels, and increased risk of adverse events. To determine...

  • High Dose Statin Treatment and New Onset Diabetes. Kaski, Juan // Cardiovascular Drugs & Therapy;Dec2011, Vol. 25 Issue 6, p571 

    The article discusses a study published in the "Journal of the American Medical Association," which revealed that intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose treatment. Information is presented on the five large statin...

  • Statins Not Associated With Reduced Cancer Risk, Meta-Analysis Shows.  // JNCI: Journal of the National Cancer Institute;2/1/2006, Vol. 98 Issue 3, p160 

    The article cites a study on the inability of common cholesterol-lowering drugs called statins to reduce cancer related deaths. This meta-analysis of 27 randomized controlled trials of statins was conducted by C. Michael White, a pharmacy doctor from the University of Connecticut and Hartford...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics