TITLE

Fetal and life course origins of serum lipids in mid-adulthood: results from a prospective cohort study

AUTHOR(S)
Gustafsson, Per E.; Janlert, Urban; Theorell, Töres; Westerlund, Hugo; Hammarström, Anne
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10, p484
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: During the past two decades, the hypothesis of fetal origins of adult disease has received considerable attention. However, critique has also been raised regarding the failure to take the explanatory role of accumulation of other exposures into consideration, despite the wealth of evidence that social circumstances during the life course impact on health in adulthood. The aim of the present prospective cohort study was to examine the contributions of birth weight and life course exposures (cumulative socioeconomic disadvantage and adversity) to dyslipidemia and serum lipids in mid-adulthood. Methods: A cohort (effective n = 824, 77%) was prospectively examined with respect to self-reported socioeconomic status as well as stressors (e.g., financial strain, low decision latitude, separation, death or illness of a close one, unemployment) at the ages of 16, 21, 30 and 43 years; summarized in cumulative socioeconomic disadvantage and cumulative adversity. Information on birth weight was collected from birth records. Participants were assessed for serum lipids (total cholesterol, low- and high-density lipoprotein cholesterol and triglycerides), apolipoproteins (A1 and B) and height and weight (for the calculation of body mass index, BMI) at age 43. Current health behavior (alcohol consumption, smoking and snuff use) was reported at age 43. Results: Cumulative life course exposures were related to several outcomes; mainly explained by cumulative socioeconomic disadvantage in the total sample (independently of current health behaviors but attenuated by current BMI) and also by cumulative adversity in women (partly explained by current health behavior but not by BMI). Birth weight was related only to triglycerides in women, independently of life course exposures, health behaviors and BMI. No significant association of either exposure was observed in men. Conclusions: Social circumstances during the life course seem to be of greater importance than birth weight for dyslipidemia and serum lipid levels in adulthood.
ACCESSION #
54098634

 

Related Articles

  • Early onset of drinking increases alcohol use in adulthood. Bonomo, Yvonne // Evidence Based Mental Health;Nov2005, Vol. 8 Issue 4, p98 

    This article presents a study which states that early onset of drinking increases alcohol use in adulthood. Mean age of onset of drinking was 15 years 6 months old. People who started drinking at age 13 or younger had significantly increased frequency of alcohol use and drinking in adulthood...

  • Health Behaviours, Socioeconomic Status, and Mortality: Further Analyses of the British Whitehall II and the French GAZEL Prospective Cohorts. Stringhini, Silvia; Dugravot, Aline; Shipley, Martin; Goldberg, Marcel; Zins, Marie; Kivimäki, Mika; Marmot, Michael; Sabia, Séverine; Singh-Manoux, Archana // PLoS Medicine;Feb2011, Vol. 8 Issue 2, p1 

    Background: Differences in morbidity and mortality between socioeconomic groups constitute one of the most consistent findings of epidemiologic research. However, research on social inequalities in health has yet to provide a comprehensive understanding of the mechanisms underlying this...

  • Cigarette Smoking and Alcohol Consumption in Relation to Cognitive Performance in Middle Age. Kalmijn, Sandra; Van Boxtel, Martin P. J.; Verschuren, Monique W. M.; Jolles, Jelle; Launer, Lenore J. // American Journal of Epidemiology;Nov2002, Vol. 156 Issue 10, p936 

    In the elderly, cigarette smoking has been related to reduced cognitive performance and moderate alcohol consumption to increased cognitive performance. It is not clear whether these associations also exist in middle age. The authors examined these relations in a population-based cohort study of...

  • Adult Consequences of Late Adolescent Alcohol Consumption: A Systematic Review of Cohort Studies. McCambridge, Jim; McAlaney, John; Rowe, Richard // PLoS Medicine;Feb2011, Vol. 8 Issue 2, p1 

    Background: Although important to public policy, there have been no rigorous evidence syntheses of the long-term consequences of late adolescent drinking. Methods and Findings: This systematic review summarises evidence from general population cohort studies of drinking between 15-19 years old...

  • Alcohol and all-cause mortality: a pooled analysis. Rehm, Jurgen; Gutjahr, Elisabeth; Gmel, Gerhard // Contemporary Drug Problems;Fall2001, Vol. 28 Issue 3, p337 

    Examines the J-shaped relationship between alcohol consumption level and all-cause mortality using a pooled analysis of cohorts age 45 and older. Relative mortality risk and confidence intervals for different categories of average volumes; Beneficial effect of moderate drinking and detrimental...

  • Validating alcohol screening scores as measures of change. Bradley, Katharine A.; Rubinsky, Anna D.; Williams, Emily C.; Lapham, Gwen T.; Chavez, Laura J.; Kivlahan, Daniel R. // Addiction Science & Clinical Practice;2013 Supplement, Vol. 8, p1 

    An abstract of the article "Validating alcohol screening scores as measures of change," by Katharine A. Bradley and colleagues is presented.

  • Being "at fault" in traffic crashes: does alcohol, cannabis, cocaine, or polydrug abuse make a difference? Chipman M L; Macdonald S; Mann R E // Injury Prevention (1353-8047);Dec2003, Vol. 9 Issue 4, p343 

    OBJECTIVE: To compare associations of alcohol, cannabis, and cocaine abuse and traffic crash risk for "at fault" crashes and all crashes. DESIGN: A historical cohort study. SETTING: Toronto, Ontario. Patients or subjects: Subjects beginning treatment at the Centre for Addictions and Mental...

  • Drinking and Alcohol-Related Harm Among Adolescents and Young Adults: International Findings. Jackson, Barry L. // Petroleum - Gas University of Ploiesti Bulletin, Educational Sci;2010, Vol. 62 Issue 2, p177 

    Frequent and hazardous rates of consumption of alcoholic beverages is particularly pronounced among adolescents and young adults in many nations around the world. This has lead to pervasive alcohol-related harm in North America, Europe and Australasia. This paper draws from an analysis of...

  • Shared Health Behaviors Among Older Mexican American Spouses. Stimpson, Jim P.; Masel, Meredith C.; Rudkin, Laura; Peek, M. Kristen // American Journal of Health Behavior;Sep/Oct2006, Vol. 30 Issue 5, p495 

    Objective: To assess the association of health behaviors among husbands and wives. Methods: Cohort study of 553 Mexican American couples aged 65 years or older from the Hispanic Established Populations for the Epidemiologic Studies of the Elderly (HEPESE). Multivariate regression analyses test...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics