Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis

Rackova, Sylva; Janu, Lubos; Kabickova, Hana
January 2010
BMC Psychiatry;2010, Vol. 10, p70
Academic Journal
Background: Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment. Methods: We examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy individuals (blood donors). We examined 41 addicted patients for the presence of BDV CIC in the serum by ELISA at the beginning of detoxification, and after eight weeks of abstinence. This is the first such study performed in patients with alcohol and drug dependence. Results: BDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in 42.86% on day 56. The control group was 37.3% positive. However, we did not detect higher BDV CIC positivity in addicted patients in comparison with blood donors (p = 0.179). The significantly higher level of BDV CIC was associated with lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached statistical significance with the lower age of addicted patients (p = 0.064). We did not find any association between BDV CIC positivity and other anamnestic and demographic characteristics. Conclusions: In our study addicted patients did not have significantly higher levels of BDV CIC than the control group. The highest levels of BDV CIC were detected in patients with lower levels of GGT and a lower age. Trial registration: This study was approved by the ethical committee of the University Hospital Medical Faculty of Charles University in Pilsen, Czech Republic (registration number 303/2001).


Related Articles

  • Neuronal Survival Strategies in the Face of RNA Viral Infection. Patterson, Catherine E.; Daley, John K.; Rall, Glenn F. // Journal of Infectious Diseases;12/2/2002 Supplement, Vol. 186, pS215 

    Neurons of the mammalian central nervous system (CNS) are an essential and largely nonrenewable cell population. Thus, viral infections that result in neuronal depletion, either by viral lysis or by induction of the cytolytic immune response, would likely lead to profound neurologic impairment....

  • Borna disease virus infection alters synaptic input of neurons in rat dentate gyrus. Heimrich, Bernd; Hesse, Daniel-Alexander; Yuan-Ju Wu; Schmid, Sonja; Schwemmle, Martin // Cell & Tissue Research;Nov2009, Vol. 338 Issue 2, p179 

    Granule cells are major targets of entorhinal afferents terminating in a laminar fashion in the outer molecular layer of the dentate gyrus. Since Borna disease virus (BDV) infection of newborn rats causes a progressive loss of granule cells in the dentate gyrus, entorhinal fibres become...

  • Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. Nobach, Daniel; Bourg, Manon; Herzog, Sibylle; Lange-Herbst, Hildburg; Encarnação, Jorge A.; Eickmann, Markus; Herden, Christiane // PLoS ONE;8/27/2015, Vol. 10 Issue 8, p1 

    Background: Many RNA viruses arise from animal reservoirs, namely bats, rodents and insectivores but mechanisms of virus maintenance and transmission still need to be addressed. The bicolored white-toothed shrew (Crocidura leucodon) has recently been identified as reservoir of the neurotropic...

  • Evolutionarily Conserved Interaction between the Phosphoproteins and X Proteins of Bornaviruses from Different Vertebrate Species. Fujino, Kan; Horie, Masayuki; Honda, Tomoyuki; Nakamura, Shoko; Matsumoto, Yusuke; Francischetti, Ivo M. B.; Tomonaga, Keizo // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Bornavirus, a non-segmented, negative-strand RNA viruses, is currently classified into several genetically distinct genotypes, such as Borna disease virus (BDV) and avian bornaviruses (ABVs). Recent studies revealed that bornavirus genotypes show unique sequence variability in the putative 59...

  • Borna Disease Virus. Hornig, Mady; Briese, Thomas; Lipkin, W. Ian // Journal of NeuroVirology;Apr2003, Vol. 9 Issue 2, p259 

    Borna disease virus, a negative-strand RNA virus, infects a wide variety of warm-blooded animals. Depending on the age of the host and the integrity of its immune response, infection may be asymptomatic or cause a broad spectrum of behavioral disorders. Unusual features of Borna disease virus...

  • The game's afoot: seeking viruses that cause chronic and degenerative neurologic and psychiatric disorder. Oldstone, M B A // Molecular Psychiatry;May2012, Vol. 17 Issue 5, p472 

    The article presents the author's views on a research paper on Borna disease virus (BDV). It is noted that the persisting viruses abort or modulate the immune response allowing the viruses to survive undetected. He comments that on the evidence that markers of BDV exposure were absent from the...

  • Bornavirus. De La Torre, Juan C.; Carbone, Kathryn M. // Springer Index of Viruses;2002, p110 

    The article offers information on bornavirus, a genus of the family Bornaviridae. The virion, genome and replication strategy of the virus are outlined. Information on the historical studies conducted on the virus from 1763 to 1996 is presented. Its genus members include the Borna disease virus....

  • Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. Zhang, L.; Xu, M.-M.; Zeng, L.; Liu, S.; Liu, X.; Wang, X.; Li, D.; Huang, R.-Z.; Zhao, L.-B.; Zhan, Q.-L.; Zhu, D.; Zhang, Y.-Y.; Xu, P.; Xie, P. // European Journal of Clinical Microbiology & Infectious Diseases;Apr2014, Vol. 33 Issue 4, p621 

    Borna disease virus (BDV) is a non-cytolytic, neurotropic RNA virus that can infect a wide variety of vertebrate species from birds and primates to humans. Several studies have been carried out to investigate whether BDV is associated with neuropsychiatric diseases. However, this association is...

  • Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive-compulsive disorder. Dietrich, D. E.; Zhang, Y.; Bode, L.; Münte, T. F.; Hauser, U.; Schmorl, P.; Richter-Witte, C.; Gödecke-Koch, T.; Feutl, S.; Schramm, J.; Ludwig, H.; Johannes, S.; Emrich, H. M. // Molecular Psychiatry;Jun2005, Vol. 10 Issue 6, p519 

    Examines the borna disease virus-specific (BDV) antibodies and viral components in peripheral blood mononuclear cells (PBMC) in humans. Isolation of infectious virus from PBMC and brain of patients; Role of BDV in the etiology of depression and obsessive-compulsive disorder (OCD); Investigation...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics