Probing model tumor interfacial properties using piezoelectric cantilevers

Yegingil, Hakki; Shih, Wan Y.; Shih, Wei-Heng
September 2010
Review of Scientific Instruments;Sep2010, Vol. 81 Issue 9, p095104
Academic Journal
Invasive malignant breast cancers are typically branchy and benign breast tumors are typically smooth. It is of interest to characterize tumor branchiness (roughness) to differentiate invasive malignant breast cancer from noninvasive ones. In this study, we examined the shear modulus (G) to elastic modulus (E) ratio, G/E, as a quantity to describe model tumor interfacial roughness using a piezoelectric cantilever capable of measuring both tissue elastic modulus and tissue shear modulus. The piezoelectric cantilever used had two lead zirconate titanate layers to facilitate all-electrical elastic (shear) modulus measurements using one single device. We constructed model tissues with tumors by embedding one-dimensional (1D) corrugated inclusions and three-dimensional (3D) spiky-ball inclusions made of modeling clay in gelatin. We showed that for smooth inclusions, G/E was 0.3 regardless of the shear direction. In contrast, for a 1D corrugated rough inclusion G/E was 0.3 only when the shear was parallel to corrugation and G/E increased with an increasing angle between the shear direction and the corrugation. When the shear was perpendicular to corrugation, G/E became >0.7. For 3D isotropic spiky-ball inclusions we showed that the G/E depended on the degree of the roughness. Using the ratio s/r of the spike length (s) to the overall inclusion radius (r) as a roughness parameter, we showed that for inclusions with s/r larger than or equal to 0.28, the G/E ratio over the inclusions was larger than 0.7 whereas for inclusions with s/r less than 0.28, the G/E decreased with decreasing s/r to around 0.3 at s/r=0. In addition, we showed that the depth limit of the G/E measurement is twice the width of the probe area of the piezoelectric cantilever.


Related Articles

  • A rutile precursor method to prepare Pb(Mg1/3Nb2/3)O3-PbTiO3 powders. Song, F. B.; Li, Q.; Li, C. H.; Zhao, S. X.; Shen, D. Z. // Journal of Materials Science;Dec2004, Vol. 39 Issue 24, p7391 

    The article reports that lead magnesium niobate-lead titanate (PMN-PT) has been widely investigated for its excellent dielectric and piezoelectric properties, which makes it an ideal material for applications in multiplayer ceramic capacitors, piezoelectric transducers and solid-state actuators....

  • Thickness effect on the dielectric, ferroelectric, and piezoelectric properties of ferroelectric lead zirconate titanate thin films. Pérez de la Cruz, J.; Joanni, E.; Vilarinho, P. M.; Kholkin, A. L. // Journal of Applied Physics;Dec2010, Vol. 108 Issue 11, p114106 

    Lead zirconate titanate (PbZr0.52Ti0.48O3-PZT) thin films with different thicknesses were deposited on Pt(111)/Ti/SiO2/Si substrates by a sol-gel method. Single perovskite phase with (111)-texture was obtained in the thinnest films, whereas with the increase in thickness the films changed to a...

  • Influence of polarization orientation on the effective properties of piezoelectric composites. Ce-Wen Nan; Weng, G.J. // Journal of Applied Physics;7/1/2000, Vol. 88 Issue 1, p416 

    Calculates the effective properties of piezoelectric composites of lead zirconate titanate and vinylidene fluoride-trifluoroethylene with different polarization status. Theory of effective properties; Effects of volume fraction and polarization orientation on the effective behavior.

  • Incorporation of lanthanide ions in lead titanate. Peláiz-Barranco, A.; Méndez-González, Y.; Arnold, D.; Saint-Grégoire, P.; Keeble, D. // Journal of Materials Science;Jan2012, Vol. 47 Issue 2, p1094 

    Lanthanide ion doping of lead titanate was investigated using structural and differential scanning calorimetry measurements. Dense ceramics samples were prepared with starting compositions, PbLnTiO, assuming A-site substitution of Ln = La, Nd, Sm, Eu, Gd and Dy, at 2 and 8 at.%. Doping with La...

  • Synthesis and optical characterization of Pb(ZrTi)O thin films on indium tin oxide/quartz substrates by a simplified sol-gel route. Rodríguez-Aranda, M.; Calderón-Piñar, F.; Mayén-Mondragón, R.; Yáñez-Limón, J. // Journal of Materials Science: Materials in Electronics;Jun2015, Vol. 26 Issue 6, p3486 

    Pb(ZrTi)O (PZT 53/47) thin films were deposited onto commercial indium tin oxide (ITO)/quartz substrates using a simplified sol-gel acetic-acid route developed at our laboratory. The films were fully crystallized to the perovskite phase with the final surface roughness remaining relatively low...

  • Piezoelectric nonlinearity of Pb(Zr,Ti)O[sub 3] thin films probed by scanning force microscopy. Shvartsman, V. V.; Kholkin, A. L.; Pertsev, N. A. // Applied Physics Letters;10/14/2002, Vol. 81 Issue 16, p3025 

    Local piezoelectric response of Pb(Zr, Ti)O[sub 3] thin films is investigated by scanning force microscopy as a function of the amplitude of driving ac field. Thus obtained local piezoelectric nonlinearity is compared with the macroscopic behavior deduced earlier from interferometric...

  • Preparation and Characterization of PZT Wafers. Seal, A.; Rao, B. S. S. Chandra; Kamath, S. V.; Sen, A.; Maiti, H. S. // AIP Conference Proceedings;7/29/2008, Vol. 1029 Issue 1, p290 

    Piezoelectric materials have recently attracted a lot of attention for ultrasonic structural health monitoring (shm) in aerospace, defence and civilian sectors, where they can act as both actuators and sensors. Incidentally, piezoelectric materials in the form of wafers (pwas-piezoelectric wafer...

  • Preparation and Characterization of PZT Thin Films. Bose, A.; Sreemany, M.; Halder, S. K.; Bhattacharyya, D. K.; Sen, Suchitra // AIP Conference Proceedings;7/29/2008, Vol. 1029 Issue 1, p279 

    In analogy with Piezoelectric Wafer Active Sensors (PWAS), Lead Zirconate Titanate (PZT) thin films also seem to be promising for Structural Health Monitoring (SHM) due to a number of reasons. Firstly, PZT thin films with well oriented domains show enhanced piezoelectric response. Secondly, PWAS...

  • Overpoling-induced property degradation in Pb(Mg1/3Nb2/3)O3–PbTiO3 single crystals of near-morphotropic phase boundary compositions. Shanthi, M.; Hoe, K. H.; Lim, C. Y. H.; Lim, L. C. // Applied Physics Letters;6/27/2005, Vol. 86 Issue 26, p262908 

    Overpoling phenomenon has been observed in flux-grown Pb(Mg1/3Nb2/3)O3–(31–32)%PbTiO3 single crystals when poled above 0.4 kV/mm at room temperature. This leads to increased property variations at intermediate poling fields (0.6–0.8 kV/mm) and to the degradation of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics