Alfa-fetoproteína y gamma-glutamiltranspeptidasa en pacientes con cirrosis hepática y carcinoma hepatocelular

Barrientos, Marcos Arango; Sierra, Santiago Naranjo; Aristizábal, Luz Adriana Ocampo; Maya, Octavio Germán Muñoz; Tobón, John Jairo Zuleta; Duque, Sergio Iván Hoyos; Arango, Gonzalo Correa; Navas, María Cristina Navas; Gutiérrez, Juan Carlos Restrepo
March 2010
Revista Colombiana de Gastroenterología;Mar2010, Vol. 25 Issue 1, p39
Academic Journal
Introduction: Hepatocellular carcinoma (HCC) is one of the complications associated with liver cirrhosis (LC). The main objective of the present study was to describe the levels of the serological markers alpha-fetoprotein (AFP) and gamma-glutamyltranspeptidase (GGT) in patients with LC and/or HCC. Methods: Cross sectional study that included 99 patients with a diagnosis of LC and/or HCC. Results: 66 (66.7%) patients had a diagnosis of LC, 23 (23.2%) had LC alongside with HCC and 10 (10.1%) had HCC without LC. AFP levels were higher in individuals with HCC associated with LC when compared with those with LC only (20 and 2.93 ng/ mL, p <0.05), the levels of GGT were also higher in patients with HCC associated with LC (208 and 109 IU/L, p <0.05). Not a single patient with HCC had normal levels of AFP and GGT simultaneously. Conclusions: In patients with HCC associated with LC levels of AFP and GGT were significantly higher than those found in individuals with LC only.


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